ReviewInternal and emergency medicine2019
Triggering agents and microbiome as environmental factors on Behçet's syndrome.
Review in Internal and emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Sex-specific analysis in Behçet's disease reveals higher genetic risk in male patients.Journal of autoimmunity · 2022Pooled it
- Cluster and correspondence analyses for oral ulcer activity related factors in Behçet's syndrome.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Oral, not gut microbiota diversity, reflects the inflammation and neoplasia in patients with uveitis and vitreoretinal lymphoma.Journal of ophthalmic inflammation and infection · 2025Article
- Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implications.Frontiers in immunology · 2025Review
- The oral microbiome and oral and upper gastrointestinal diseases.Journal of oral microbiology · 2024Review
- Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome.The EMBO journal · 2023Article
- Intestinal Behcet's Disease: A Review of the Immune Mechanism and Present and Potential Biological Agents.International journal of molecular sciences · 2023Review
- Contribution of Arab countries to Behçet disease research: a PubMed-based bibliometric and altmetric analysis.Rheumatology international · 2022Observational
- Biologic treatments in Behçet's disease.European journal of rheumatology · 2021Article
- Comparison of Sociodemographic Features Between Behçet Uveitis and Other Non-infectious UveitisTurkish journal of ophthalmology · 2021Article
- Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet's Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Advances in the Treatment of Behcet's Disease.Current rheumatology reports · 2021Review
- Article
- Genetics of Behçet's Disease: Functional Genetic Analysis and Estimating Disease Heritability.Frontiers in medicine · 2021Review
- Pathogenesis of Behçet's Syndrome: Genetic, Environmental and Immunological Factors.Frontiers in medicine · 2021Review
- Oral Health and Its Aetiological Role in Behçet's Disease.Frontiers in medicine · 2021Review
- Decreasing incidence and severity of Behçet’s disease: a changing trend in epidemiological spectrum possibly associated with oral healthTurkish journal of medical sciences · 2020Review
- The geographic and clinical clusters of Behçet's syndrome.Internal and emergency medicine · 2020Article
- Article
- Behçet's syndrome: focus on pathogenetic background, clinical phenotypes and specific treatments.Internal and emergency medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental and other triggering factors are suggested to cause the onset and the clinical relapses of Behçet's syndrome (BS), a multi-systemic inflammatory disorder. In this review, environmental factors are discussed according to their interactions with etiopathogenesis, immune response and disease activity. Stress is a common self-triggering factor for most BS patients. Stimuli such as some foods can activate oral ulcers, and may be linked to the histamine content of the food. Oral/skin trauma and menstruation associated with hormonal factors aggravate, whereas allergy/atopy seem to alleviate the symptoms of BS. Infections are associated with BS, and microbial stimuli can activate inflammation in mucosal surfaces with increased Th1/Th17 responses. Fecal and oral microbiome patterns change in diversity and composition in BS. Better oral hygiene applications and anti-microbial interventions might be helpful to suppress oral ulcers in BS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.