ArticleEuropean radiology2019
New MRI features improve subtype classification of hepatocellular adenoma.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring radiological characteristics in beta-catenin-mutated hepatocellular adenoma: a systematic review and meta-analysis.Abdominal radiology (New York) · 2026Pooled it
- Gd-EOB-DTPA-enhanced hepatobiliary phase MRI characteristics of inflammatory hepatic adenoma.BMC medical imaging · 2025Article
- Insights into hepatocellular adenomas in Asia: molecular subtypes, clinical characteristics, imaging features, and hepatocellular carcinoma risks.Journal of liver cancer · 2025Article
- Case Report: Hepatocellular adenoma due to long-term oral stanozolol administration.Frontiers in medicine · 2025Article
- Hepatocellular adenoma update: diagnosis, molecular classification, and clinical course.The British journal of radiology · 2024Review
- WFUMB Review Paper. Incidental Findings in Otherwise Healthy Subjects, How to Manage: Liver.Cancers · 2024Review
- Sonic hedgehog hepatocellular adenoma: magnetic resonance imaging features and correlation with histology.European radiology · 2024Article
- Assessment of a multivariable model using MRI-radiomics, age and sex for the classification of hepatocellular adenoma subtypes.Research in diagnostic and interventional imaging · 2024Article
- Key CT and MRI findings of drug-associated hepatobiliary and pancreatic disorders.Japanese journal of radiology · 2024Review
- [Multidisciplinary experts consensus on diagnosis and treatment of precancerous lesions of hepatocellular carcinoma (2023 version)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- [Analysis of MRI features of hepatocyte nuclear factor 1α-inactivated hepatocellular adenoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Differentiation of hepatocellular adenoma by subtype and hepatocellular carcinoma in non-cirrhotic liver by fractal analysis of perfusion MRI.Insights into imaging · 2022Article
- Long-term outcomes following resection of hepatocellular adenomas with small foci of malignant transformation or malignant adenomas.JHEP reports : innovation in hepatology · 2021Article
- Scoping review of clinical practice guidelines on the management of benign liver tumours.BMJ open gastroenterology · 2021Article
- A case study of glycogen storage disease type Ia presenting with multiple hepatocellular adenomas: an analysis by gadolinium ethoxybenzyl-diethylenetriamine-pentaacetic acid magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2021Article
- Guidelines for the Treatment of Hepatocellular Adenoma in the Era of Molecular Biology: An Experience-Based Surgeons' Perspective.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Hepatospecific MR contrast agent uptake on hepatobiliary phase can be used as a biomarker of marked β-catenin activation in hepatocellular adenoma.European radiology · 2021Article
- Hepatocellular Carcinoma with Macroscopic Fat Metamorphosis: A Case Series.Journal of clinical imaging science · 2021Article
- Hepatic tumors: pitfall in diagnostic imaging.Acta bio-medica : Atenei Parmensis · 2020Review
- Hepatocellular adenomas: is there additional value in using Gd-EOB-enhanced MRI for subtype differentiation?European radiology · 2020Article
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10 authors.
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Abstract
objectiveMRI is crucial for the classification of hepatocellular adenomas (HCA) into subtypes. Our objective was to review and increase MRI criteria for subtype classification and define the limits.
methodsPathological and radiological data of 116 HCAs were retrospectively analyzed to investigate MRI features of HCA pathological subtypes. Risk for complication was also evaluated with regard to subtype and tumor size.
results38/43 (88%) HNF1α-mutated HCAs (H-HCAs) were discriminated by (i) fatty component (homogeneous or heterogeneous) and (ii) hypovascular pattern, with a sensitivity of 88% and a specificity of 97%. 51/58 (88%) inflammatory HCAs (IHCAs) displayed features of sinusoidal dilatation (SD) including three different patterns (global SD, atoll sign, and a new "crescent sign" corresponding to a partial peripheral rim, hyperintense on T2W and/or arterial phase with persistent delayed enhancement). Sensitivity was 88% and specificity 100%. However, some HCA remained unclassifiable by MRI: HCA remodeled by necrotic/hemorrhagic changes covering > 50% of the lesion, H-HCAs without steatosis, IHCAs without SD, β-catenin-mutated and unclassified HCAs. Regarding malignant transformation (5/116) and bleeding (24/116), none was observed when the HCA diameter was smaller than 5.2 cm and 4.2 cm, respectively.
conclusionBased on the largest series evaluated until now, we identified several non-described MRI features and propose new highly sensitive and specific MRI criteria. With the addition of these new features, 88% of the two main HCA subtypes could be identified. KEY POINTS: • HNF1α-mutated hepatocellular adenomas (H-HCA) are characterized by the presence of fat and hypovascular pattern in MRI. • Inflammatory hepatocellular adenomas (I-HCA) are characterized by different patterns translating sinusoidal dilatation including the newly described crescent sign. • No MRI specific pattern was identified for β-catenin-mutated HCA (b-HCA).
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