Evidence map›Paper›PMID 30523453›Full record

ArticleEuropean radiology2019

Diabetes risk assessment with imaging: a radiomics study of abdominal CT.

Chun-Qiang Lu, Yuan-Cheng Wang, Xiang-Pan Meng, Hai-Tong Zhao, Chu-Hui Zeng, Weiwei Xu, Ya-Ting Gao, Shenghong Ju

Abstract read
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In one paragraph

Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  9. Article
  10. Imaging evaluation of the pancreas in diabetic patients.Abdominal radiology (New York) · 2022
    Review
  11. Article
  12. A Case Control Study of the Seroprevalence ofJournal of pancreatic cancer · 2021
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chun-Qiang LuJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China.
Yuan-Cheng WangJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China.
Xiang-Pan MengJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China.
Hai-Tong ZhaoLab of Image and Signal Processing, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Chu-Hui ZengJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China.
Weiwei XuJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China.
Ya-Ting GaoJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China.
Shenghong JuJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China. jsh0836@hotmail.com.ORCID http://orcid.org/0000-0001-5041-7865
Zhongda Hospital Southeast University · CNSoutheast University · CN

Funding

National Nature Science Foundation of China 81525014the Jiangsu Provincial Special Program of Medical Science BL2013029the Key Research and Development Program of Jiangsu Province BE2016782
6 · The paper itself

Abstract

objectivesTo identify CT markers for screening of early type 2 diabetes and assessment of the risk of incident diabetes using a radiomics method.

methodsThe medical records of 26,947 inpatients were reviewed. A total of 690 patients were selected and allocated to a primary cohort, a validation cohort, and a prediction cohort and used to build prediction models for diabetes. Three radiomics signatures were constructed using CT image features extracted from three regions of interest, i.e., in the pancreas, liver, and psoas major muscle. By incorporating radiomics signatures and other markers, we built a radiomics nomogram that could be used to screen for early diabetes and predict future diabetes.

resultsOf the three abdominal organs for which radiomics signature were constructed, that of the pancreas showed the best discriminatory power for early diabetes screening and prediction (C-statistics of 0.833, 0.846, and 0.899 for the primary cohort, validation cohort, and prediction cohort, respectively). The sensitivity and specificity of the nomogram for prediction of 3-year incident diabetes were 0.827 and 0.807, respectively.

conclusionsThis study presents alternative radiomics markers that have potential for use in screening for undiagnosed type 2 diabetes and prediction of 3-year incident diabetes. KEY POINTS: • CT images may provide useful information to evaluate the risk of developing diabetes. • Radiomics score for diabetes prediction is based on subtle changes of abdominal organs detected by CT. • The radiomics signature of pancreas, a combination of five features of CT images, is efficient for early diabetes screening and prediction of future diabetes (AUC > 0.8).

Indexed as

NomogramsAdipose TissueAgedDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedMultidetector Computed TomographyRadiography, AbdominalReproducibility of ResultsRisk AssessmentAdipose tissueDiabetes mellitusMultidetector computed tomographyPancreas

Identifiers

PMID30523453
OpenAlexW2902002152

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.