Evidence map›Paper›PMID 30523263›Full record

ArticleNature communications2018

Why rankings of biomedical image analysis competitions should be interpreted with care.

Lena Maier-Hein, Matthias Eisenmann, Annika Reinke, Sinan Onogur, Marko Stankovic, Patrick Scholz, Tal Arbel, Hrvoje Bogunovic, Andrew P Bradley, Aaron Carass and 28 more

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 135 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  20. BaselineFrontiers in oncology · 2026
    Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors.

Lena Maier-HeinDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. l.maier-hein@dkfz.de.ORCID http://orcid.org/0000-0003-4910-9368
Matthias EisenmannDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0713-8761
Annika ReinkeDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Sinan OnogurDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Marko StankovicDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Patrick ScholzDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Tal ArbelCentre for Intelligent Machines, McGill University, Montreal, QC, H3A0G4, Canada.
Hrvoje BogunovicChristian Doppler Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology, Medical University Vienna, 1090, Vienna, Austria.
Andrew P BradleyScience and Engineering Faculty, Queensland University of Technology, Brisbane, QLD, 4001, Australia.
Aaron CarassDepartment of Electrical and Computer Engineering, Department of Computer Science, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID http://orcid.org/0000-0003-4939-5085
Carolin FeldmannDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Alejandro F FrangiCISTIB - Center for Computational Imaging & Simulation Technologies in Biomedicine, The University of Leeds, Leeds, Yorkshire, LS2 9JT, UK.ORCID http://orcid.org/0000-0002-2675-528X
Peter M FullDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4326-8026
Bram van GinnekenDepartment of Radiology and Nuclear Medicine, Medical Image Analysis, Radboud University Center, 6525 GA, Nijmegen, The Netherlands.
Allan HanburyInstitute of Information Systems Engineering, TU Wien, 1040, Vienna, Austria.
Katrin HonauerHeidelberg Collaboratory for Image Processing (HCI), Heidelberg University, 69120, Heidelberg, Germany.
Michal KozubekCentre for Biomedical Image Analysis, Masaryk University, 60200, Brno, Czech Republic.ORCID http://orcid.org/0000-0001-7902-589X
Bennett A LandmanElectrical Engineering, Vanderbilt University, Nashville, TN, 37235-1679, USA.ORCID http://orcid.org/0000-0001-5733-2127
Keno MärzDivision of Computer Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Oskar MaierInstitute of Medical Informatics, Universität zu Lübeck, 23562, Lübeck, Germany.
Klaus Maier-HeinDivision of Medical Image Computing (MIC), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Bjoern H MenzeInstitute for Advanced Studies, Department of Informatics, Technical University of Munich, 80333, Munich, Germany.
Henning MüllerInformation System Institute, HES-SO, Sierre, 3960, Switzerland.ORCID http://orcid.org/0000-0001-6800-9878
Peter F NeherDivision of Medical Image Computing (MIC), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5285-7554
Wiro NiessenDepartments of Radiology, Nuclear Medicine and Medical Informatics, Erasmus MC, 3015 GD, Rotterdam, The Netherlands.
Nasir RajpootDepartment of Computer Science, University of Warwick, Coventry, CV4 7AL, UK.
Gregory C SharpDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Korsuk SirinukunwattanaInstitute of Biomedical Engineering, University of Oxford, Oxford, OX3 7DQ, UK.
Stefanie SpeidelDivision of Translational Surgical Oncology (TCO), National Center for Tumor Diseases Dresden, 01307, Dresden, Germany.
Christian StockDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Danail StoyanovCentre for Medical Image Computing (CMIC) & Department of Computer Science, University College London, London, W1W 7TS, UK.
Abdel Aziz TahaData Science Studio, Research Studios Austria FG, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-7604-9041
Fons van der SommenDepartment of Electrical Engineering, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.ORCID http://orcid.org/0000-0002-3593-2356
Ching-Wei WangAIExplore, NTUST Center of Computer Vision and Medical Imaging, Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, 106, Taiwan.
Marc-André WeberInstitute of Diagnostic and Interventional Radiology, University Medical Center Rostock, 18051, Rostock, Germany.
Guoyan ZhengInstitute for Surgical Technology and Biomechanics, University of Bern, Bern, 3014, Switzerland.ORCID http://orcid.org/0000-0003-4173-0379
Pierre JanninUniv Rennes, Inserm, LTSI (Laboratoire Traitement du Signal et de l'Image) - UMR_S 1099, Rennes, 35043, Cedex, France.ORCID http://orcid.org/0000-0002-7415-071X
Annette Kopp-SchneiderDivision of Biostatistics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Funding

Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1M
Brain Image Analysis Tools for Quantitative Longitudinal Assessment of MSR01NS070906 · NINDS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PHAM, DZUNG L · 2010 to 2014
$1.7M
Medical Research Council MR/P015476/1NIBIB NIH HHS R01 EB017230NINDS NIH HHS R01 NS070906Wellcome Trust
6 · The paper itself

Abstract

International challenges have become the standard for validation of biomedical image analysis methods. Given their scientific impact, it is surprising that a critical analysis of common practices related to the organization of challenges has not yet been performed. In this paper, we present a comprehensive analysis of biomedical image analysis challenges conducted up to now. We demonstrate the importance of challenges and show that the lack of quality control has critical consequences. First, reproducibility and interpretation of the results is often hampered as only a fraction of relevant information is typically provided. Second, the rank of an algorithm is generally not robust to a number of variables such as the test data used for validation, the ranking scheme applied and the observers that make the reference annotations. To overcome these problems, we recommend best practice guidelines and define open research questions to be addressed in the future.

Indexed as

Biomedical ResearchBiomedical TechnologyDiagnostic ImagingHumansImage Processing, Computer-AssistedReproducibility of ResultsSurveys and QuestionnairesTechnology Assessment, Biomedical

Identifiers

PMID30523263
PMCPMC6284017

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.