Evidence map›Paper›PMID 30523116›Full record

ArticleThe Journal of general physiology2019

Sarcomere length-dependent effects on Ca

King-Lun Li, Mei Methawasin, Bertrand C W Tanner, Henk L Granzier, R John Solaro, Wen-Ji Dong

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Evidence for a role of adverse sarcomere signaling in atrial fibrillation induction.Journal of molecular and cellular cardiology plus · 2026
    Review
  3. Myosin-actin crossbridge independent sarcomere length induced CaJournal of molecular and cellular cardiology · 2025
    Article
  4. CaJournal of molecular and cellular cardiology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. New Insights in RBM20 Cardiomyopathy.Current heart failure reports · 2020
    Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

King-Lun LiGene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA.
Mei MethawasinDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ.ORCID 0000-0002-2509-1936
Bertrand C W TannerIntegrative Physiology and Neuroscience, Washington State University, Pullman, WA.ORCID 0000-0003-1711-8526
Henk L GranzierDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ.ORCID 0000-0002-9516-407X
R John SolaroThe Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL.
Wen-Ji DongGene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA dongwenji@wsu.edu.ORCID 0000-0002-9846-7084
Washington State University · USUniversity of Arizona · USUniversity of Illinois Chicago · US

Funding

Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DE TOMBE, PIETER P. · 2000 to 2020
$42.4M
Kinetics of Cardiac Myofilament ActivationR01HL080186 · NHLBI · WASHINGTON STATE UNIVERSITY · PI DONG, WEN-JI · 2005 to 2013
$3.4M
Myofilament-based mechanisms of diastolic dysfunction in HFpEFR01HL118524 · NHLBI · UNIVERSITY OF ARIZONA · PI GRANZIER, HENK L., LEWINTER, MARTIN M · 2014 to 2017
$2.5M
Titin-Based Adaptations of Cardiac FunctionR01HL115988 · NHLBI · UNIVERSITY OF ARIZONA · PI GRANZIER, HENK L. · 2013 to 2019
$2.3M
NHLBI NIH HHS P01 HL062426NHLBI NIH HHS R01 HL080186NHLBI NIH HHS R01 HL115988NHLBI NIH HHS R01 HL118524
6 · The paper itself

Abstract

Cardiac performance is tightly regulated at the cardiomyocyte level by sarcomere length, such that increases in sarcomere length lead to sharply enhanced force generation at the same Ca

Indexed as

ActinsAnimalsCalciumMiceMyocardial ContractionMyocardiumMyocytes, CardiacMyosinsProtein DomainsProtein KinasesSarcomeresTroponin CActinsCalciumMyosinsProtein Kinasestitin protein, mouseTroponin C

Identifiers

PMID30523116
PMCPMC6314383
OpenAlexW2903612888

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.