ArticleScience (New York, N.Y.)2018
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
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Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
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Who cites it
83 citing papers in PubMed, 137 citations in OpenAlex.
- New thinking for the next generation of antimalarials.EMBO molecular medicine · 2026Review
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- Genetic analysis of pyrimidine biosynthetic enzymes in Plasmodium falciparum.PLoS pathogens · 2026Article
- A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation.Nature communications · 2026Article
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- Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum.Malaria journal · 2026Article
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- Genetic analysis of pyrimidine biosynthetic enzymes inbioRxiv : the preprint server for biology · 2025Article
- Identification of α-Azacyclic Acetamide-Based Inhibitors ofACS infectious diseases · 2025Article
- Article
- Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity.Cell chemical biology · 2025Article
- A Machine Learning Platform for Isoform-Specific Identification and Profiling of Human Carbonic Anhydrase Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Biogenesis of CytochromesACS infectious diseases · 2025Article
- Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b.European journal of medicinal chemistry · 2024Article
- Global Health Priority Box─Proactive Pandemic Preparedness.ACS infectious diseases · 2024Review
- Screening the Global Health Priority Box against Plasmodium berghei liver stage parasites using an inexpensive luciferase detection protocol.Malaria journal · 2024Article
- Biogenesis of cytochromesbioRxiv : the preprint server for biology · 2024Article
- Candida albicans' inorganic phosphate transport and evolutionary adaptation to phosphate scarcity.PLoS genetics · 2024Article
- In vitro evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells.Scientific reports · 2024Article
- Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1.ACS infectious diseases · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 10 institutions in 5 countries.
Yevgeniya Antonova-KochSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.ORCID 0000-0003-2862-0407
Stephan MeisterSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.ORCID 0000-0003-2436-7037
Matthew AbrahamSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.ORCID 0000-0003-0272-4443
Madeline R LuthSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.ORCID 0000-0001-9059-1200
Sabine OttilieSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.
Amanda K LukensHarvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-9560-7643
Tomoyo Sakata-KatoThe Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.ORCID 0000-0002-8089-5101
Manu VanaerschotDivision of Infectious Diseases, Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0002-9141-2347
Edward OwenDepartment of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-7331-4658
Juan Carlos JadoSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.
Steven P MaherCenter for Tropical and Emerging Global Diseases, University of Georgia, 500 D. W. Brooks Drive, Athens, GA 30602, USA.ORCID 0000-0002-9560-5656
Jaeson CallaSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.ORCID 0000-0003-4812-3168
David PlouffeThe Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
Yang ZhongThe Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
Kaisheng ChenThe Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
Victor ChaumeauShoklo Malaria Research Unit, Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.ORCID 0000-0003-0171-2176
Amy J ConwayCenter for Tropical and Emerging Global Diseases, University of Georgia, 500 D. W. Brooks Drive, Athens, GA 30602, USA.
Case W McNamaraThe Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
Maureen IbanezThe Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.ORCID 0000-0001-6953-7023
Kerstin GagaringThe Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
Fernando Neria SerranoTres Cantos Medicines Development Campus, Malaria DPU, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.ORCID 0000-0002-4417-2248
Korina EribezSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.ORCID 0000-0002-5986-7253
Cullin McLean TaggardSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.
Andrea L CheungSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.
Christie LincolnSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.ORCID 0000-0001-5605-5746
Biniam AmbachewSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.ORCID 0000-0002-1405-9578
Melanie RouillierMedicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.ORCID 0000-0001-7028-764X
Dionicio SiegelSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA.
François NostenShoklo Malaria Research Unit, Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.ORCID 0000-0002-7951-0745
Dennis E KyleCenter for Tropical and Emerging Global Diseases, University of Georgia, 500 D. W. Brooks Drive, Athens, GA 30602, USA.ORCID 0000-0002-0238-965X
Francisco-Javier GamoMedicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.
Yingyao ZhouThe Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
Manuel LlinásDepartment of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-6173-5882
David A FidockDivision of Infectious Diseases, Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0001-6753-8938
Dyann F WirthHarvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-8604-4455
Jeremy BurrowsMedicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.ORCID 0000-0001-8448-6068
Brice CampoMedicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.ORCID 0000-0002-6425-5577
Elizabeth A WinzelerSchool of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA. ewinzeler@ucsd.edu.ORCID 0000-0002-4049-2113
University of California San Diego · USGenomics Institute of the Novartis Research Foundation · USMedicines for Malaria Venture · CHBroad Institute · USUniversity of Georgia · USColumbia University Irving Medical Center · USPennsylvania State University · USUniversity of Oxford · GBGlaxoSmithKline (Spain) · ESUniversity of Montana · US
Funding
SYNTHETIC SYSTEMSP50GM085764 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2010 to 2018
$23.3MTargeting the Mitochondrion of P. falciparumR01AI093716 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI WIRTH, DYANN F · 2012 to 2020
$4.8MDiscovery of chemically validated malaria liver stage targetsR01AI090141 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2011 to 2019
$3.4MDefining the targets of broad intervention antimalarial agentsR01AI103058 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2013 to 2016
$2.6MNIAID NIH HHS R01 AI090141NIAID NIH HHS R01 AI093716NIAID NIH HHS R01 AI103058NIGMS NIH HHS P50 GM085764
Abstract
To discover leads for next-generation chemoprotective antimalarial drugs, we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing
Indexed as
ChemopreventionDrug DiscoveryAntimalarialsDrug Evaluation, PreclinicalHumansMalariaMitochondriaPlasmodiumAntimalarials
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