Evidence map›Paper›PMID 30523062›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

A Comparative Study of the Pharmacokinetics of Clozapine

Daicia C Allen, Timothy L Carlson, Yan Xiong, Jian Jin, Kathleen A Grant, Verginia C Cuzon Carlson

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024
    Review
  4. Article
  5. Article
  6. Synthesis and structure of clozapineActa crystallographica. Section E, Crystallographic communications · 2022
    Article
  7. Applications of chemogenetics in non-human primates.Current opinion in pharmacology · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Daicia C AllenDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon (D.C.A., K.A.G., V.C.C.C.); Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon (T.L.C., K.A.G., V.C.C.C.); and Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (Y.X., J.J.).ORCID 0000-0002-4767-1237
Timothy L CarlsonDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon (D.C.A., K.A.G., V.C.C.C.); Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon (T.L.C., K.A.G., V.C.C.C.); and Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (Y.X., J.J.).
Yan XiongDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon (D.C.A., K.A.G., V.C.C.C.); Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon (T.L.C., K.A.G., V.C.C.C.); and Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (Y.X., J.J.).
Jian JinDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon (D.C.A., K.A.G., V.C.C.C.); Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon (T.L.C., K.A.G., V.C.C.C.); and Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (Y.X., J.J.).
Kathleen A GrantDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon (D.C.A., K.A.G., V.C.C.C.); Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon (T.L.C., K.A.G., V.C.C.C.); and Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (Y.X., J.J.).ORCID 0000-0002-0380-7219
Verginia C Cuzon CarlsonDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon (D.C.A., K.A.G., V.C.C.C.); Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon (T.L.C., K.A.G., V.C.C.C.); and Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (Y.X., J.J.) cuzoncar@ohsu.edu.ORCID 0000-0002-8858-3241
Icahn School of Medicine at Mount Sinai · USOregon Health & Science University · USOregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Stress and Ethanol Self-Administration in MonkeysU01AA013510 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KATHLEEN A GRANT · 2002 to 2026
$11.8M
Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
DREADD2.0: AN ENHANCED CHEMOGENETIC TOOLKITU01MH105892 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIN, JIAN, KASH, THOMAS L. · 2014 to 2016
$3.0M
Analysis of the nucleus accumbens in ethanol's discriminative stimulus effectsF31AA024660 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLEN, DAICIA · 2015 to 2017
$120k
NIAAA NIH HHS F31 AA024660NIAAA NIH HHS R24 AA019431NIAAA NIH HHS U01 AA013510NIH HHS P51 OD011092NIMH NIH HHS U01 MH105892
6 · The paper itself

Abstract

Translating chemogenetic techniques from nonhuman primates to potential clinical applications has been complicated in part due to in vivo conversion of the chemogenetic actuator, clozapine

Indexed as

AnimalsAntipsychotic AgentsClozapineFemaleHydrochloric AcidMacaca mulattaMaleAntipsychotic AgentsClozapineclozapine N-oxideHydrochloric Acid

Identifiers

PMID30523062
PMCPMC6337003
OpenAlexW2904158249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.