Trial reportHaematologica2019
Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease.
Trial report in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.BMC medicine · 2020Pooled it
- Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease.American journal of hematology · 2025Trial
- Cerebral oxygen metabolism in adults with sickle cell disease.American journal of hematology · 2020Trial
- Computational Modeling of Collateral Circulation and Arteriolar Vasodilation in Ischemic Tissue Perfusion.Annals of biomedical engineering · 2026Article
- Observational
- Micro-Embolic Events and Their Clearing in the Brain. A Narrative Review.Acta physiologica (Oxford, England) · 2025Review
- Reduction of carbonic anhydrase activity is associated with amelioration of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Article
- Cerebral Hemodynamic Responses to Disease-Modifying and Curative Sickle Cell Disease Therapies.Neurology · 2025Article
- Correlation of breathing task derived cerebrovascular reactivity with baseline CBF, OEF and CMROFrontiers in neurology · 2025Article
- Cerebral hemodynamics and oxygen metabolism in patients with milder and severe forms of sickle cell disease and thalassemia.HemaSphere · 2024Article
- Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence.bioRxiv : the preprint server for biology · 2024Article
- Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions.European journal of neurology · 2024Article
- Hemodynamic imaging parameters in brain metastases patients - Agreement between multi-delay ASL and hypercapnic BOLD.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias.Magnetic resonance imaging · 2023Article
- Comparing end-tidal CONeuroImage · 2023Article
- Silent infarction in sickle cell disease is associated with brain volume loss in excess of infarct volume.Frontiers in neurology · 2023Article
- The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease.Hematology/oncology clinics of North America · 2022Review
- Assessment of functional shunting in patients with sickle cell disease.Haematologica · 2022Article
- Presurgical Magnetic Resonance Imaging Indicators of Revascularization Response in Adults With Moyamoya Vasculopathy.Journal of magnetic resonance imaging : JMRI · 2022Article
- Cerebral oxygen metabolic stress is increased in children with sickle cell anemia compared to anemic controls.American journal of hematology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sickle cell disease is characterized by chronic hemolytic anemia and vascular inflammation, which can diminish the vasodilatory capacity of the small resistance arteries, making them less adept at regulating cerebral blood flow. Autoregulation maintains adequate oxygen delivery, but when vasodilation is maximized, the low arterial oxygen content can lead to ischemia and silent cerebral infarcts. We used magnetic resonance imaging of cerebral blood flow to quantify whole-brain cerebrovascular reserve in 36 adult patients with sickle cell disease (mean age, 31.9±11.3 years) and 11 healthy controls (mean age, 37.4±15.4 years), and we used high-resolution 3D FLAIR magnetic resonance imaging to determine the prevalence of silent cerebral infarcts. Cerebrovascular reserve was calculated as the percentage change in cerebral blood flow after a hemodynamic challenge with acetazolamide. Co-registered lesion maps were used to demonstrate prevalent locations for silent cerebral infarcts. Cerebral blood flow was elevated in patients with sickle cell disease compared to controls (median [interquartile range]: 82.8 [20.1]
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.