ArticleDiabetes2019
PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity.
Open access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.
- MAM kinases: physiological roles, related diseases, and therapeutic perspectives-a systematic review.Cellular & molecular biology letters · 2025Pooled it
- Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review).Molecular medicine reports · 2026Review
- Hepatocyte Growth Hormone Receptor Ablation Is Associated With Aging Phenotypes and Hepatic Mitochondrial Dysfunction.Aging cell · 2026Article
- SSUH2 Promotes Odontogenic Differentiation of SCAPs via the FOXM1/PDK1-Mediated Regulation of Mitochondrial Function.International endodontic journal · 2026Article
- Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review).International journal of molecular medicine · 2026Review
- Metabolic Kinases as Regulators of Inter-Organelle Communication in Aging and Age-Related Diseases.Aging cell · 2026Review
- Article
- The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026Review
- Targeting Endothelial PDK4-EndoMT Feedback Loop Mitigates the Development of Thoracic Aortic Dissection in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Pharmacological Inhibition of Pyruvate Dehydrogenase Kinase 4 Enhances Insulin Sensitivity in Mouse Models of Diabetes and Obesity.Journal of obesity & metabolic syndrome · 2026Article
- Single-cell RNA sequencing analysis reveals the evolution and regulatory features of specialized endothelial cell subsets in non-traumatic osteonecrosis of the femoral head.Biology direct · 2026Article
- Melatonin promotes skeletal muscle mitochondria-associated endoplasmic reticulum membrane contacts and restores organellar membrane integrity and phospholipid composition in Zücker diabetic fatty rats of both sexes.Cell communication and signaling : CCS · 2026Article
- BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes.Molecular cell · 2026Article
- 18β-Glycyrrhetinic acid mitigates adverse effects of high-fat diets on liver fibrosis in largemouth bass (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Article
- Mitochondrial medicine in obesity: a scoping review.Open medicine (Warsaw, Poland) · 2026Review
- Long-chain saturated free fatty acids induce pancreatic β-cell lipotoxic stress via HFrontiers in endocrinology · 2026Article
- Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta.Scientific reports · 2025Article
- Crosstalk Between the Endoplasmic Reticulum and Mitochondria in Skeletal Muscle: Implications for Meat Quality.Animals : an open access journal from MDPI · 2025Review
- Inducible skeletal muscle-specific p53 deletion alleviates high-fat diet-induced insulin resistance by modulating mitochondria-associated membrane in obese mice.Redox biology · 2025Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 9 institutions in 2 countries.
Themis ThoudamDepartment of Biomedical Science, The Graduate School, Kyungpook National University, Daegu, Republic of Korea.
Chae-Myeong HaDepartment of Biomedical Science, The Graduate School, Kyungpook National University, Daegu, Republic of Korea.
Jaechan LeemDepartment of Immunology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Dipanjan ChandaLeading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
Jong-Seok ParkDepartment of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Hyo-Jeong KimElectron Microscopy Research Center, Korea Basic Science Institute, Ochang, Chungbuk, Republic of Korea.
Jae-Han JeonLeading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
Yeon-Kyung ChoiLeading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Yang Hoon HuhElectron Microscopy Research Center, Korea Basic Science Institute, Ochang, Chungbuk, Republic of Korea.
Tae-Hwan KwonDepartment of Biomedical Science, The Graduate School, Kyungpook National University, Daegu, Republic of Korea.
Keun-Gyu ParkLeading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.ORCID 0000-0002-8403-1298
Robert A HarrisDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN.
Kyu-Sang ParkDepartment of Physiology, Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Gangwon-Do, Republic of Korea.
Hyun-Woo RheeDepartment of Chemistry, Seoul National University, Seoul, Republic of Korea.
In-Kyu LeeLeading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea leei@knu.ac.kr.ORCID 0000-0002-2261-7269
Kyungpook National University Hospital · KRKyungpook National University · KRKorea Basic Science Institute · KRYonsei University · KRDaegu Catholic University · KRIndiana University School of MedicineRichard L. Roudebush VA Medical Center · USSeoul National University · KRUlsan National Institute of Science and Technology · KR
Funding
Translational Research and Evolving Alcoholic hepatitis Treatment (TREAT-IU)U01AA021840 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI NAGA P CHALASANI, Olawale Ojo · 2012 to 2026
$8.1MNovel biomarkers as a clinical tool for excessive alcohol use screeningR01AA025208 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, TU, WANZHU · 2016 to 2020
$1.7MSestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver diseaseR01DK107682 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE, LIANGPUNSAKUL, SUTHAT · 2016 to 2019
$1.4MLong noncoding RNAs in alcoholic liver diseaseR21AA024935 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, WANG, LI · 2016 to 2017
$431kSerum Proteomic Profiles as Biomarkers of Abusive Alcohol ConsumptionI01CX000361 · VA · RLR VA MEDICAL CENTER · PI LIANGPUNSAKUL, SUTHAT · 2012 to 2025
–CSRD VA I01 CX000361NIAAA NIH HHS R01 AA025208NIAAA NIH HHS R21 AA024935NIAAA NIH HHS U01 AA021840NIDDK NIH HHS R01 DK107682
Abstract
Mitochondria-associated endoplasmic reticulum membrane (MAM) is a structural link between mitochondria and endoplasmic reticulum (ER). MAM regulates Ca
Indexed as
AnimalsCalciumCell LineEndoplasmic Reticulum StressImmunoblottingImmunoprecipitationInsulinMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionMitochondriaMuscle, SkeletalObesityCalciumInsulinPdk4 protein, mouseProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseReactive Oxygen Species
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.