ArticleNeuron2019
How the Internally Organized Direction Sense Is Used to Navigate.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Optogenetic stimulation of memory-tagged neurons elicits endogenous patterns of neural activity.bioRxiv : the preprint server for biology · 2025Article
- Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex.eLife · 2025Article
- Medial entorhinal cortex mediates learning of context-dependent interval timing behavior.Nature neuroscience · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Hippocampal sequences span experience relative to rewards.bioRxiv : the preprint server for biology · 2024Article
- A manifold neural population code for space in hippocampal coactivity dynamics independent of place fields.Cell reports · 2023Article
- Do Place Cells Dream of Deceptive Moves in a Signaling Game?Neuroscience · 2023Review
- Article
- Cerebellar control of a unitary head direction sense.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Action-driven remapping of hippocampal neuronal populations in jumping rats.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The grid code for ordered experience.Nature reviews. Neuroscience · 2021Review
- Is hippocampal remapping the physiological basis for context?Hippocampus · 2020Review
- The head direction cell network: attractor dynamics, integration within the navigation system, and three-dimensional properties.Current opinion in neurobiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Head-direction cells preferentially discharge when the head points in a particular azimuthal direction, are hypothesized to collectively function as a single neural system for a unitary direction sense, and are believed to be essential for navigating extra-personal space by functioning like a compass. We tested these ideas by recording medial entorhinal cortex (MEC) head-direction cells while rats navigated on a familiar, continuously rotating disk that dissociates the environment into two spatial frames: one stationary and one rotating. Head-direction cells degraded directional tuning referenced to either of the externally referenced spatial frames, but firing rates, sub-second cell-pair action potential discharge relationships, and internally referenced directional tuning were preserved. MEC head-direction cell ensemble discharge collectively generates a subjective, internally referenced unitary representation of direction that, unlike a compass, is inconsistently registered to external landmarks during navigation. These findings indicate that MEC-based directional information is subjectively anchored, potentially providing for navigation without a stable externally anchored direction sense.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.