ArticleNeuron2019
Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04293783 (Efficacy of Lactobacillus Reuteri in Managing Social Deficits in Children With Autistic Spectrum Disorder), which is not on this map. Cited by 455 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Lactobacillus Reuteri in Managing Social Deficits in Children With Autistic Spectrum Disorder: a Randomized Clinical Trial With Evaluation of Gut Microbiota and Metabolomics Profiles
Who cites it
455 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Efficacy of pharmacological and microbiota-based therapies in preclinical models of autism spectrum disorder: a systematic review.Molecular psychiatry · 2026Pooled it
- Pooled it
- Effects of Probiotic Supplementation on Core Symptoms of Autism Spectrum Disorder in Children.Nutrients · 2026Pooled it
- Global trends and future perspectives in autism spectrum disorder and gut microbiota research: a comprehensive bibliometric analysis.Frontiers in neuroscience · 2026Pooled it
- Microbiota-based interventions for autism spectrum disorder: a systematic review of efficacy and clinical potential.Frontiers in microbiology · 2025Pooled it
- Effects of probiotics on patients with Prader-Willi syndrome: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2025Pooled it
- Influential articles in autism and gut microbiota: bibliometric profile and research trends.Frontiers in microbiology · 2024Pooled it
- The role of the oxytocinergic system in oral microbiome composition in children with autism: evidence from a randomized controlled trial of intranasal oxytocin.Translational psychiatry · 2026Trial
- Altered Gut Microbiota and Short-chain Fatty Acids in Chinese Children with Constipated Autism Spectrum Disorder.Scientific reports · 2023Trial
- Article
- The putative role of the microbiota in the development of neuropsychiatric disorders following early childhood malnutrition.Gut microbes · 2026Review
- Vagal sensing of altered gut microbiota links to externalizing behaviors.Gut microbes · 2026Article
- HPSC-derived mesenchymal stromal cells ameliorate murine autistic-like phenotypes through activating oxytocinergic neurons.Science advances · 2026Article
- Disruption of major Ptchd1 isoforms causes autistic traits in social behavior and communication.Molecular psychiatry · 2026Article
- Transcriptomic landscape of microglia in mouse models of social dysfunction and oxytocin-mediated recovery.iScience · 2026Article
- Research Progress on Bidirectional Regulation of the Microbiota-Gut-Brain Axis in Autism Spectrum Disorder Based on the Immune-Metabolic-Endocrine Interactive Network.Biomolecules · 2026Review
- Fecal microbiota from chronically stressed donors transfers behavioral and prefrontal cortex gene expression alterations to healthy recipient mice.Neurobiology of stress · 2026Article
- Altered Intestinal Neurotransmission in Autism Spectrum Disorder: Expanding the Molecular Landscape of the Gut-Brain Axis.Digestive diseases and sciences · 2026Article
- Gut microbiota-derived 5-HTP penetrates the host blood-brain barrier and ameliorates autism symptoms.Acta pharmaceutica Sinica. B · 2026Article
- Microbiota-dependent enterocyte oxytocin signaling in autism: mechanisms and translational implications.Molecular psychiatry · 2026Article
395 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Currently, there are no medications that effectively treat the core symptoms of Autism Spectrum Disorder (ASD). We recently found that the bacterial species Lactobacillus (L.) reuteri reverses social deficits in maternal high-fat-diet offspring. However, whether the effect of L. reuteri on social behavior is generalizable to other ASD models and its mechanism(s) of action remains unknown. Here, we found that treatment with L. reuteri selectively rescues social deficits in genetic, environmental, and idiopathic ASD models. Interestingly, the effects of L. reuteri on social behavior are not mediated by restoring the composition of the host's gut microbiome, which is altered in all of these ASD models. Instead, L. reuteri acts in a vagus nerve-dependent manner and rescues social interaction-induced synaptic plasticity in the ventral tegmental area of ASD mice, but not in oxytocin receptor-deficient mice. Collectively, treatment with L. reuteri emerges as promising non-invasive microbial-based avenue to combat ASD-related social dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.