Evidence map›Paper›PMID 30522811›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2019

A Preliminary Study of Clinical Trial Enrollment Decisions Among People With Mild Cognitive Impairment and Their Study Partners.

Chelsea G Cox, Mary M Ryan B A, Daniel L Gillen, Joshua D Grill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

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  15. Reasons for undergoing amyloid imaging among cognitively unimpaired older adults.Annals of clinical and translational neurology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chelsea G CoxInstitute for Memory Impairments and Neurological Disorders (CGC, DLG, JDG), University of California, Irvine, Irvine, CA.
Mary M Ryan B Athe Department of Statistics (MMR, DLG), University of California, Irvine, Irvine, CA.
Daniel L GillenInstitute for Memory Impairments and Neurological Disorders (CGC, DLG, JDG), University of California, Irvine, Irvine, CA; the Department of Statistics (MMR, DLG), University of California, Irvine, Irvine, CA.
Joshua D GrillInstitute for Memory Impairments and Neurological Disorders (CGC, DLG, JDG), University of California, Irvine, Irvine, CA; the Department of Psychiatry and Human Behavior (JDG), University of California, Irvine, Irvine, CA; the Department of Neurobiology and Behavior (JDG), University of California, Irvine, Irvine, CA; Institute for Clinical and Translational Science (JDG), University of California, Irvine, Irvine, CA. Electronic address: jgrill@uci.edu.
University of California, Irvine · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathologyR01AG053555 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Michael A Yassa · 2017 to 2026
$17.0M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
NCATS NIH HHS UL1 TR001414NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG053555NIA NIH HHS T32 AG000096
6 · The paper itself

Abstract

objectiveAll Alzheimer disease (AD) clinical trials, including those enrolling patients with mild cognitive impairment (MCI), require dyadic participation. The purpose of this study was to elucidate how people with MCI and their study partners decide whether to enroll in clinical trials.

methodsThis was a mixed methods interview study. We interviewed patient participants with a consensus research diagnosis of MCI and their study partners. Interviews examined how dyads decide whether to enroll in a clinical trial and whether AD biomarker testing affects willingness to enroll.

resultsThough most MCI patients and study partners would decide in partnership whether to enroll in a clinical trial, agreement was lower among nonspousal, compared with spousal, dyads. Deterrents to enrollment included concerns about patient safety and inconvenience, especially for study partners. Motivators to enrollment included altruism, the desire to contribute to research, hope for patient benefit, and the desire to learn more about the patient's condition. When asked open-ended questions about motivators to enroll in trials, few patients cited access to biomarker testing specifically, though most expressed a desire to undergo biomarker testing when asked directly.

conclusionSpousal and nonspousal MCI dyads may approach clinical trial decisions differently. Future research should investigate how AD biomarker testing affects participants' willingness to enroll in trials.

Indexed as

AdultAgedAged, 80 and overAlzheimer DiseaseClinical Trials as TopicCognitive DysfunctionDecision MakingFemaleHumansLogistic ModelsMaleMiddle AgedMotivationPatient ParticipationSexual PartnersSpousesclinical trialsprodromal Alzheimer diseaseRecruitment

Identifiers

PMID30522811
PMCPMC6387840
OpenAlexW2899158634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.