ArticleAcademic radiology2019
Using Hyperpolarized Xenon-129 MRI to Quantify Early-Stage Lung Disease in Smokers.
Article in Academic radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Using hyperpolarised xenon magnetic resonance imaging to explore breathlessness in long COVID: results from the EXPLAIN study.ERJ open research · 2026Article
- Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025Review
- Evaluation of an integrated variable flip angle protocol to estimate coil BMagnetic resonance in medicine · 2025Article
- Article
- Regional variations in hyperpolarized 129Xe lung MRI: Insights from CSI-CSSR and CSSR in healthy and irradiated rat models.Magnetic resonance in medicine · 2025Article
- Hyperpolarized Xenon-129 MRI: Narrative Review of Clinical Studies, Testing, and Implementation of Advanced Pulmonary In Vivo Imaging and Its Diagnostic Applications.Diagnostics (Basel, Switzerland) · 2025Review
- Using the full power of multiple hyperpolarizedEuropean radiology · 2025Article
- Assessment of pulmonary physiological changes caused by aging, cigarette smoking, and COPD with hyperpolarizedEuropean radiology · 2024Article
- The Importance of Early Chronic Obstructive Pulmonary Disease: A Lecture from 2022 Asian Pacific Society of Respirology.Tuberculosis and respiratory diseases · 2023Article
- Evaluation of injuries caused by coronavirus disease 2019 using multi-nuclei magnetic resonance imaging.Magnetic resonance letters · 2021Review
- Measuring pulmonary gas exchange using compartment-selective xenon-polarization transfer contrast (XTC) MRI.Magnetic resonance in medicine · 2021Article
- Validating in vivo hyperpolarizedMagnetic resonance in medicine · 2021Article
- Modern pulmonary imaging of bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021Review
- Investigating biases in the measurement of apparent alveolar septal wall thickness with hyperpolarized 129Xe MRI.Magnetic resonance in medicine · 2020Article
- Diagnosis and Treatment of Early Chronic Obstructive Lung Disease (COPD).Journal of clinical medicine · 2020Review
- Molecular Sensing with Host Systems for HyperpolarizedMolecules (Basel, Switzerland) · 2020Review
- Emphysema Index Based on HyperpolarizedRadiology · 2020Article
- Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolvedJournal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei.Magma (New York, N.Y.) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
RATIONALE AND
objectivesHyperpolarized xenon-129 magnetic resonance (MR) provides sensitive tools that may detect early stages of lung disease in smokers before it has progressed to chronic obstructive pulmonary disease (COPD) apparent to conventional spirometric measures. We hypothesized that the functional alveolar wall thickness as assessed by hyperpolarized xenon-129 MR spectroscopy would be elevated in clinically healthy smokers before xenon MR diffusion measurements would indicate emphysematous tissue destruction. MATERIALS AND
methodsUsing hyperpolarized xenon-129 MR we measured the functional septal wall thickness and apparent diffusion coefficient of the gas phase in 16 subjects with smoking-related COPD, 9 clinically healthy current or former smokers, and 10 healthy never smokers. All subjects were age-matched and characterized by conventional pulmonary function tests. A total of 11 data sets from younger healthy never smokers were added to determine the age dependence of the septal wall thickness measurements.
resultsIn healthy never smokers the septal wall thickness increased by 0.04 μm per year of age. The healthy smoker cohort exhibited normal pulmonary function test measures that did not significantly differ from the never-smoker cohort. The age-corrected septal wall thickness correlated well with diffusion capacity for carbon monoxide (R
conclusionFunctional alveolar wall thickness assessed by hyperpolarized xenon-129 MR allows discrimination between healthy subjects and healthy smokers and could become a powerful new measure of early-stage lung disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.