Evidence map›Paper›PMID 30522780›Full record

ArticleNeuropeptides2019

Skeletal phenotype of the neuropeptide Y knockout mouse.

Natalie K Y Wee, Benjamin P Sinder, Sanja Novak, Xi Wang, Chris Stoddard, Brya G Matthews, Ivo Kalajzic

Open access · greenAbstract read
In one paragraph

Article in Neuropeptides, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Inhibition of CGRP signaling impairs fracture healing in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Crosstalk between Bone and Nerves within Bone.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  15. Divergent effects of peripheral and global neuropeptide Y deletion.Journal of musculoskeletal & neuronal interactions · 2020
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Nerves in Bone: Evolving Concepts in Pain and Anabolism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Natalie K Y WeeDepartment of Reconstructive Sciences, Farmington, CT 06030, USA.
Benjamin P SinderDepartment of Reconstructive Sciences, Farmington, CT 06030, USA.
Sanja NovakDepartment of Reconstructive Sciences, Farmington, CT 06030, USA.
Xi WangDepartment of Reconstructive Sciences, Farmington, CT 06030, USA.
Chris StoddardGenetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Brya G MatthewsDepartment of Reconstructive Sciences, Farmington, CT 06030, USA; Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1023, New Zealand.
Ivo KalajzicDepartment of Reconstructive Sciences, Farmington, CT 06030, USA. Electronic address: ikalaj@uchc.edu.
UConn Health · USUniversity of Auckland · NZ

Funding

Notch Signaling and Bone Fracture HealingR01AR055607 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Kurt David Hankenson, IVO Kalajzic · 2011 to 2026
$6.3M
Growth Factor Based on Enhancement of Bone RepairR01AR070813 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KALAJZIC, IVO · 2017 to 2021
$1.7M
NIAMS NIH HHS R01 AR055607NIAMS NIH HHS R01 AR070813
6 · The paper itself

Abstract

Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which cells within the skeleton express Npy and establish a model that will enable us to differentiate effects of NPY derived from different cell types. We have generated the NPY floxed (NPY

Indexed as

Alkaline PhosphataseAnimalsBone and BonesBone DensityFemaleMaleMiceMice, KnockoutNeuropeptide YOsteogenesisReceptors, Neuropeptide YAlkaline PhosphataseNeuropeptide YReceptors, Neuropeptide YBoneBone strengthConditional mouseCortical boneNeuropeptide Y (NPY)

Identifiers

PMID30522780
PMCPMC6326877
OpenAlexW2902332017

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.