ArticleBMC pharmacology & toxicology2018
Potential drug incompatibilities in the neonatal intensive care unit: a network analysis approach.
Article in BMC pharmacology & toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Physical and Chemical Compatibility of Medications Commonly Used in Critically Ill Patients With Balanced Crystalloids: A Systematic Review.The Annals of pharmacotherapy · 2024Pooled it
- A Network Visualization Query System for Multidrug Compatibility Based on a WeChat Mini Program: Preliminary Usability and Efficiency Evaluation.JMIR formative research · 2026Article
- Stability and compatibility of phentolamine mesylate combined with furosemide in common infusion solutions for pediatric critical care.Frontiers in pediatrics · 2026Article
- Compatibility Investigation of a Steroid and Two Antibiotics with Heparin for the Prevention of Catheter Occlusion in Neonatal Intensive Care Units.Methods and protocols · 2025Article
- Evaluation of the Impact of Infusion Set Design on the Particulate Load Induced by Vancomycin-Piperacillin/Tazobactam Incompatibility.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Y-Site Compatibility Studies of Parenteral Nutrition and Other Intravenous Medications in Neonatal and Pediatric Patients: A Review of the Literature Evidence.Pharmaceutics · 2024Review
- Implementation of pharmacists' monitoring for intravenous drug compatibility.European journal of hospital pharmacy : science and practice · 2023Article
- Frequently acquired drugs in neonatal intensive care and their physical compatibility.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Co-administration of drugs with parenteral nutrition in the neonatal intensive care unit-physical compatibility between three components.European journal of pediatrics · 2022Article
- Drug compatibility in neonatal intensive care units: gaps in knowledge and discordances.European journal of pediatrics · 2021Article
- Physical compatibility of alprostadil with selected drugs commonly used in the neonatal intensive care units.European journal of pediatrics · 2021Article
- Safe Practice of Y-Site Drug Administration: The Case of Colistin and Parenteral Nutrition.Pharmaceutics · 2020Article
- Pharmaceutical Quality of Selected Metronidazole and Ciprofloxacin Infusions Marketed in South Eastern Nigeria.Drug, healthcare and patient safety · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is little information on the frequency of drug incompatibilities in neonatal intensive care units (NICU) and the agents most commonly involved in them. The objective of the study was to characterize potential Drug Incompatibilities (DI) in the NICU by frequency, type and combination of drugs.
methodsBetween August 2015 and December 2016, all neonates admitted for more than 24 h and who received any drug treatment were included in this cohort study conducted in the NICU of a teaching maternity hospital in Brazil. Patient data were collected from patient records and prescription orders, and the compatibilities of all drug pairs were classified using the Trissel's™ 2 IV Compatibility tool. Network analysis was performed in order to visualize the drug pairs commonly involved in potential DI.
resultsThe study population consisted of 281 neonates with a median NICU length of stay of 11 days (range 2-184) and received 1343 intravenous medications. A total of 1114 potential DI were identified, 469 (42.1%) were restricted compatibilities, 348 (31.2%) unknown compatibilities and 297 (26.7%) documented incompatibilities. The incidence of documented incompatibilities in the NICU was 25.0% patient-days (95% confidence interval (CI) 19.4-30.7% patient-days). Incompatible potential DI affected 46.3% (95%CI 40.3-52.3%) of the neonates. Ampicillin (408 of 1114 pairs), gentamicin (216 of 1114 pairs) and aminophylline (197 of 1114 pairs) were the main medicines involved in potential DI.
conclusionPotential DI are extremely common in NICU, with half of the population susceptible to simultaneous administration of incompatible medications. More research is needed to understand the actual drug incompatibilities and their clinical outcomes.
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