Evidence map›Paper›PMID 30522497›Full record

Trial reportJournal of neuroengineering and rehabilitation2018

Generalizing remotely supervised transcranial direct current stimulation (tDCS): feasibility and benefit in Parkinson's disease.

Bryan Dobbs, Natalie Pawlak, Milton Biagioni, Shashank Agarwal, Michael Shaw, Giuseppina Pilloni, Marom Bikson, Abhishek Datta, Leigh Charvet

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02746705 (Pilot Study of Transcranial Direct Current Stimulation), which is not on this map. Cited by 50 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02746705 nacompletednot on this map

Pilot Study of Transcranial Direct Current Stimulation (tDCS)

TypeinterventionalSponsorNYU Langone HealthRan2016 to 2018Enrolled31ConditionsMultiple SclerosisArmsTranscranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation, Cognitive Training Program
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bryan DobbsNew York University Langone Health, New York, USA.
Natalie PawlakTufts School of Medicine, Boston, USA.
Milton BiagioniNew York University Langone Health, New York, USA.
Shashank AgarwalNew York University Langone Health, New York, USA.
Michael ShawNew York University Langone Health, New York, USA.
Giuseppina PilloniNew York University Langone Health, New York, USA.
Marom BiksonCity College of New York, New York, USA.
Abhishek DattaSoterix Medical, New York, USA.
Leigh CharvetNew York University Langone Health, New York, USA. Leigh.charvet@nyumc.org.ORCID 0000-0003-4429-9713

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has been shown to improve common symptoms of neurological disorders like depressed mood, fatigue, motor deficits and cognitive dysfunction. tDCS requires daily treatment sessions in order to be effective. We developed a remotely supervised tDCS (RS-tDCS) protocol for participants with multiple sclerosis (MS) to increase accessibility of tDCS, reducing clinician, patient, and caregiver burden. The goal of this protocol is to facilitate home use for larger trials with extended treatment periods. In this study we determine the generalizability of RS-tDCS paired with cognitive training (CT) by testing its feasibility in participants with Parkinson's disease (PD).

methodsFollowing the methods in our MS protocol development, we enrolled sixteen participants (n = 12 male, n = 4 female; mean age 66 years) with PD to complete ten open-label sessions of RS-tDCS paired with CT (2.0 mA × 20 min) at home under the remote supervision of a trained study technician. Tolerability data were collected before, during, and after each individual session. Baseline and follow-up measures included symptom inventories (fatigue and sleep) and cognitive assessments.

resultsRS-tDCS was feasible and tolerable for patients with PD, with at-home access leading to high protocol compliance. Side effects were mostly limited to mild sensations of transient itching and burning under the electrode sites. Similar to prior finding sin MS, we found preliminary efficacy for improvement of fatigue and cognitive processing speed in PD.

conclusionsRS-tDCS paired with CT is feasible for participants with PD to receive at home treatment. Signals of benefit for reduced fatigue and improved cognitive processing speed are consistent across the PD and MS samples. RS-tDCS can be generalized to provide tDCS to a range of patients with neurologic disorders for at-home rehabilitation.

trial registrationClinicalTrials.gov Identifier: NCT02746705 . Registered April 21st 2016.

Indexed as

AgedFeasibility StudiesFemaleHumansMaleParkinson DiseaseTelerehabilitationTranscranial Direct Current StimulationMultiple sclerosisParkinson’s diseasetDCSTelerehabilitationTranscranial direct current stimulation

Identifiers

PMID30522497
PMCPMC6284269

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.