Evidence map›Paper›PMID 30522479›Full record

ArticleBMC pulmonary medicine2018

WISP1 mediates lung injury following hepatic ischemia reperfusion dependent on TLR4 in mice.

Yao Tong, Zhuang Yu, Renlingzi Zhang, Xibing Ding, Zhixia Chen, Quan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yao TongDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, China.
Zhuang YuDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, China.
Renlingzi ZhangDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, China.
Xibing DingDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, China.
Zhixia ChenDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, China.
Quan LiDepartment of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, China. quanligene@126.com.
Shanghai East Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatic ischemia-reperfusion injury (IRI) is a common pathological phenomenon, which causes hepatic injury as well as remote organ injuries such as the lung. Several mediators, such as oxidative stress, Ca

methodsMale C57BL/6 mice were used to examine the expression and role of WISP1 in the pathogenesis of lung injuries after hepatic IRI and explore its potential mechanisms in mediating lung injuries.

resultsWe found WISP1 was upregulated in lung tissues following hepatic IRI. Treatment with anti-WISP1 antibody ameliorated lung injuries with alteration of cytokine profiles. Administration with rWISP1 aggravated lung injuries following hepatic IRI through excessive production of proinflammatory cytokines and inhibition of anti-inflammatory cytokines.

conclusionsIn this study, we concluded that WISP1 contributed to lung injuries following hepatic IRI through TLR4 pathway.

Indexed as

LiverLung InjuryAnimalsCCN Intercellular Signaling ProteinsCytokinesMiceMice, Inbred C57BLNeutrophil InfiltrationOxidative StressProto-Oncogene ProteinsReperfusion InjurySignal TransductionToll-Like Receptor 4Up-RegulationCCN4 protein, mouseCCN Intercellular Signaling ProteinsCytokinesProto-Oncogene ProteinsTlr4 protein, mouseToll-Like Receptor 4Hepatic ischemia-reperfusion injuryInflammatory cascadesToll like receptorWNT1 inducible signaling pathway protein 1

Identifiers

PMID30522479
PMCPMC6282316
OpenAlexW2902176783

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.