ArticleBMC urology2018
Early post-operative serum albumin level predicts survival after curative nephrectomy for kidney cancer: a retrospective study.
Article in BMC urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Geriatric nutritional risk index as a predictor for postoperative complications in patients with solid cancers: a meta-analysis.Frontiers in oncology · 2024Pooled it
- Impact of D3 lymph node dissection extent on postoperative bowel function and nutritional status in right-sided colon cancer: a prospective randomized controlled trial.International journal of surgery (London, England) · 2026Trial
- Prognostic significance of hematological parameters and albumin in BCMA-targeted CAR-T therapy for multiple myeloma.Frontiers in immunology · 2025Article
- Predictive value of serum albumin levels on cancer survival: a prospective cohort study.Frontiers in oncology · 2024Article
- [Pre-operative prognostic nutritional index as a predictive factor for prognosis in non-metastatic renal cell carcinoma treated with surgery].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Serum Albumin Kinetics in Major Ovarian, Gastrointestinal, and Cervico Facial Cancer Surgery.International journal of environmental research and public health · 2022Article
- A clinical investigation of the association between perioperative oral management and prognostic nutritional index in patients with digestive and urinary cancers.Current oncology (Toronto, Ont.) · 2020Article
- Association of serum albumin level with incidence and mortality of overt hepatic encephalopathy in cirrhosis during hospitalization.Therapeutic advances in gastroenterology · 2019Article
- The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer.OncoTargets and therapy · 2019Article
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Authors and funding
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Funding
Abstract
backgroundPrevious studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin level has not been well-documented as a prognostic factor in patients with renal cell cancer.
methodsWe retrospectively included patients hospitalized for kidney cancer from January 2009 to May 2014. First, the receiver operating characteristic analysis was used to define the best cut-off of an early post-operative serum albumin level in determining the prognosis, from which survival analysis was performed.
resultsA total of 329 patients were included. The median duration of follow-up was 54.8 months. Patients with an early post-operative serum albumin level < 32 g/L had a significantly shorter median recurrence-free survival (RFS; 49.1 versus 56.5 months, P = 0.001) and median overall survival (OS; 52.2 versus 57.0 months, P = 0.049) than patients with an early post-operative serum albumin level ≥ 32 g/L. After adjusting for age, BMI, tumor stage, post-operative hemoglobin concentration, and pre-operative albumin, globulin, and hemoglobin levels, multivariate Cox regression showed that an early post-operative serum albumin level < 32 g/L was an independent prognostic factor associated with a decreased RFS (HR = 3.60; 95% CI,1.05-12.42 [months], P = 0.042) and decreased OS (HR = 9.95; 95% CI, 1.81-54.80 [months], P = 0.008).
conclusionAn early post-operative serum albumin level < 32 g/L is an independent prognostic factor leading to an unfavorable RFS and OS. Prospective trials and further studies involving additional patients are warranted.
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