ArticleBehavioural brain research2019
Enhanced anxiety-like behavior emerges with weight gain in male and female obesity-susceptible rats.
Article in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Immune dysregulation and gut microbiota: Connection to health and disease development.Neural regeneration research · 2026Article
- Therapeutic effects of bee venom on high fat diet induced obesity and behavioral changes.Biologia futura · 2026Article
- Impact of high-fat diet and feeding time on daily anxious-like behaviors in aged male rats.Behavioral and brain functions : BBF · 2026Article
- Cafeteria and Fast-Food Diets Induce Neuroinflammation, Social Deficits, but a Different Cardiometabolic Phenotype.Nutrients · 2025Article
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- Evaluation of the Effects of Diet-Induced Obesity in Zebrafish (Nutrients · 2024Article
- High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats.Biological research · 2024Article
- Article
- Comparison of intermittent fasting and voluntary wheel running on physical and cognitive abilities in high-fat diet-induced obese rats.PloS one · 2023Article
- Leptin deficiency-caused behavioral change - A comparative analysis using EthoVision and DeepLabCut.Frontiers in neuroscience · 2023Article
- Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms.Frontiers in cellular and infection microbiology · 2023Review
- Cigarette smoke and nicotine effects on behavior in HIV transgenic rats.Behavioural brain research · 2022Article
- Influence of High Energy Diet and Polygenic Predisposition for Obesity on Postpartum Health in Rat Dams.Frontiers in physiology · 2021Article
- Obesity and Mental Health: A Longitudinal, Cross-Cultural Examination in Germany and China.Frontiers in psychology · 2021Article
- Supplementation with CombinedMicroorganisms · 2020Article
- Sex and region-specific effects of high fat diet on PNNs in obesity susceptible rats.Physiology & behavior · 2020Article
- Eating "junk food" has opposite effects on intrinsic excitability of nucleus accumbens core neurons in obesity-susceptible versus -resistant rats.Journal of neurophysiology · 2019Article
- Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus.Frontiers in molecular neuroscience · 2019Article
- Symbiotic probiotic communities with multiple targets successfully combat obesity in high-fat-diet-fed mice.Gut microbesArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Epidemiological data suggest that body mass index and obesity are strong risk factors for depression and anxiety. However, it is difficult to separate cause from effect, as predisposition to obesity may enhance susceptibility to anxiety, or vice versa. Here, we examined the effect of diet and obesity on anxiety-like behaviors in male and female selectively bred obesity-prone and obesity-resistant rats, and outbred Sprague-Dawley rats. We found that when obesity-prone and obesity-resistant rats do not differ in weight or fat mass, measures of anxiety-like behavior in the elevated plus maze and open field are similar between the two groups. However, once weight and fat mass diverge, group differences emerge, with greater anxiety in obesity-prone relative to obesity-resistant rats. This same pattern was observed for males and females. Interestingly, even when obesity-resistant rats were "forced" to gain fat mass comparable to obesity-prone rats (via prolonged access to 60% high-fat diet), anxiety-like behaviors did not differ from lean chow fed controls. In addition, a positive correlation between anxiety-like behaviors and adiposity were observed in male but not in female obesity-prone rats. Finally, diet-induced weight gain in and of itself was not sufficient to increase measures of anxiety in outbred male rats. Together, these data suggest that interactions between susceptibility to obesity and physiological alterations accompanying weight gain may contribute to the development of enhanced anxiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.