ArticleGastroenterology2019
Racial Disparities in Incidence of Young-Onset Colorectal Cancer and Patient Survival.
Article in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Guideline
- A systematic review of methods to estimate colorectal cancer incidence using population-based cancer registries.BMC medical research methodology · 2022Pooled it
- Statistical methods for measuring trends in colorectal cancer incidence in registries: A systematic review.Frontiers in oncology · 2022Pooled it
- Survival in Young-Onset Metastatic Colorectal Cancer: Findings From Cancer and Leukemia Group B (Alliance)/SWOG 80405.Journal of the National Cancer Institute · 2022Trial
- Artificial Intelligence-Guided Analysis of WNT Pathway Alterations: Associations with Genomic Burden and Survival Across African American and Non-Hispanic White Populations, Age Groups, and FOLFOX Treatment in Colorectal Cancer.International journal of molecular sciences · 2026Article
- Early-onset colorectal cancer: epidemiology, risk factors, and implications for clinical practice.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Early-onset colorectal cancer: a comprehensive review reframing hypotheses and defining research priorities.International journal of colorectal disease · 2026Review
- Exploring the role of marital status on survival and stage at diagnosis in early-onset colorectal cancer by race/ethnicity.Scientific reports · 2026Article
- Evaluation of the genome-informed risk assessment (GIRA) approach from eMERGE in an independent health system.medRxiv : the preprint server for health sciences · 2026Article
- Characteristics and Prognosis of Early-Onset vs. Late-Onset Colon Cancer: A Propensity Score Matching Analysis Based on Histology.Cancer medicine · 2026Article
- Effect of Race and Tumor Subsite on Survival Outcome in Early- and Late-Onset Colorectal Cancer.Cancers · 2026Article
- Racial, Ethnic, and Socioeconomic Survival Disparities in Early-Onset Metastatic Colorectal Cancer.JAMA network open · 2026Article
- Fusobacterium nucleatum enhances oxaliplatin resistance in colon cancer by increasing PVT1 expression.Journal of translational medicine · 2025Article
- Review
- Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000-2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database.Cancer medicine · 2025Article
- Integrated analysis of single-cell and bulk RNA-sequencing to predict prognosis and therapeutic response for colorectal cancer.Scientific reports · 2025Article
- Early-Onset Colorectal Cancer Survival by Race and Ethnicity in a Large Community-Based Insured Population.Gastro hep advances · 2025Article
- Temporal Trends in Racial and Gender Disparities of Early Onset Colorectal Cancer in the United States: An Analysis of the CDC WONDER Database.Journal of gastrointestinal cancer · 2024Review
- Racial and Ethnic Variation in Survival in Early-Onset Colorectal Cancer.JAMA network open · 2024Article
- Comparing SEER and NCDB: a case study using colorectal cancer.Cancer causes & control : CCC · 2024Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsIncreasing rates of young-onset colorectal cancer (CRC) have attracted substantial research and media attention, but we know little about racial disparities among younger adults with CRC. We examined racial disparities in young-onset CRC by comparing CRC incidence and relative survival among younger (<50-year-old) adults in 2 time periods.
methodsUsing data from the Surveillance, Epidemiology, and End Results program of cancer registries, we estimated CRC incidence rates (per 100,000 persons 20-49 years old) from 1992 through 2014 for different periods (1992-1996 vs 2010-2014) and races (white vs black). Relative survival was calculated as the ratio of observed survival to expected survival in a comparable cancer-free population.
resultsFrom 1992-1996 to 2010-2014, CRC incidence increased from 7.5 to 11.0 per 100,000 in white individuals and from 11.7 to 12.7 per 100,000 in black individuals. The increase in rectal cancer was larger in whites (from 2.7 to 4.5 per 100,000) than in blacks (from 3.4 to 4.0 per 100,000); in the 2010-2014 period, blacks and whites had similar rates of rectal cancer. Compared with whites, blacks had smaller increases in relative survival with proximal colon cancer but larger increases in survival with rectal cancer (from 55.3% to 70.8%).
conclusionIn an analysis of the Surveillance, Epidemiology, and End Results database, we found racial disparities in incidence of young-onset CRC and patient survival for cancer of the colon but minimal difference for rectal cancer. Well-documented and recent increases in young-onset CRC have largely been due to increases in rectal cancer, especially in whites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.