ArticlePloS one2018
Baroreflex function, haemodynamic responses to an orthostatic challenge, and falls in haemodialysis patients.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Differences in circulatory dynamics and skeletal muscle blood flow during exercise between post-dialysis and non-dialysis days in hemodialysis patients.International urology and nephrology · 2026Article
- Ten tips on how to prevent falls in dialysis patients.Clinical kidney journal · 2026Review
- Variability of baroreceptor reflex assessed by tilt table test in a patient undergoing pulmonary vein isolation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Observational
- Effect of increased fear of falling on falls in patients undergoing HD: A narrative review.Fukushima journal of medical science · 2025Review
- Low muscle strength and physical function contribute to falls in hemodialysis patients, but not muscle mass.Clinical and experimental nephrology · 2024Article
- Baroreflex Sensitivity Assessment Using the Sequence Method with Delayed Signals in End-Stage Renal Disease Patients.Sensors (Basel, Switzerland) · 2022Article
- Relationship between Nutrition-Related Problems and Falls in Hemodialysis Patients: A Narrative Review.Nutrients · 2022Review
- Factors associated with fear of falling in hemodialysis patients.International urology and nephrology · 2021Article
- Cerebral blood flow regulation in end-stage kidney disease.American journal of physiology. Renal physiology · 2020Article
- The relative importance of frailty, physical and cardiovascular function as exercise-modifiable predictors of falls in haemodialysis patients: a prospective cohort study.BMC nephrology · 2020Observational
- Risk of falls in people with chronic kidney disease and related factors.Revista latino-americana de enfermagem · 2020Article
- Multimodal Monitoring of Cardiovascular Responses to Postural Changes.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStage 5 chronic kidney disease patients on haemodialysis (HD) often present with dizziness and pre-syncopal events as a result of the combined effect of HD therapy and cardiovascular disease. The dysregulation of blood pressure (BP) during orthostasis may be implicated in the aetiology of falls in these patients. Therefore, we explored the relationship between baroreflex function, the haemodynamic responses to a passive orthostatic challenge, and falls in HD patients.
methodsSeventy-six HD patients were enrolled in this cross-sectional study. Participants were classified as "fallers" and "non-fallers" and completed a passive head up tilting to 60o (HUT-60°) test on an automated tilt table. ECG signals, continuous and oscillometric BP measurements and impedance cardiography were recorded. The following variables were derived from these measurements: heart rate (HR) stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR), number of baroreceptor events, and baroreceptor effectiveness index (BEI).
resultsThe forty-four participants who were classified as fallers (57.9%) had a lower number of baroreceptor events (6.5±8.5 vs 14±16.7, p = .027) and BEI (20.8±24.2% vs 33.4±23.3%, p = .025). In addition, fallers experienced a significantly larger drop in systolic (-6.4±10.9 vs -0.4±7.7 mmHg, p = .011) and diastolic (-2.7±7.3 vs 1.8±6 mmHg, p = .027) oscillometric BP from supine to HUT-60° compared with non-fallers. None of the variables taken for the analysis were significantly associated with falls in multivariate logistic regression analysis.
conclusionsThis cross-sectional comparison indicates that, at rest, HD patients with a positive history of falls present with a lower count of baroreceptor sequences and BEI. Short-term BP regulation warrants further investigation as BP drops during a passive orthostatic challenge may be implicated in the aetiology of falls in HD.
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