ArticlePloS one2018
Non-professional caregiver burden is associated with the severity of patients' cognitive impairment.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The Mental Health of Caregivers and Their Patients With Dementia During the COVID-19 Pandemic: A Systematic Review.Frontiers in psychology · 2021Pooled it
- JAK4D, a first-in-class thyrotropin-releasing hormone analogue, reverses scopolamine-induced memory deficits.Brain communications · 2026Article
- Exploring the relationship between cognitive function and frailty in middle-aged and older adults Chinese adults: evidence from the CHARLS database.Frontiers in public health · 2026Article
- Efficacy of butylphthalide in preventing cognitive decline in ischaemic stroke survivors: a 12-month prospective following-up study.Stroke and vascular neurology · 2025Article
- Does the relationship between stress and quality of life differ among informal caregivers of older adults with Alzheimer's disease and children with autism spectrum disorder? Results from a cross-sectional survey.Journal of patient-reported outcomes · 2025Article
- Pre- and post- COVID-19 trends related to dementia caregiving on Twitter.Scientific reports · 2025Article
- Caregiving-Related Depression Increases Neuroinflammation in Spousal Caregivers to Individuals With Cognitive Impairment: A Longitudinal Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Determinants of Depression in Caregivers of Geriatric Patients in Jeddah, Saudi Arabia: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- Predictors of live-in migrant caregiver employment for people with dementia in Taiwan.Journal of the Chinese Medical Association : JCMA · 2024Article
- The associations between unmet needs with protective factors, risk factors and outcomes among care partners of community-dwelling persons living with dementia.Aging & mental health · 2023Article
- How both positive and burdensome caregiver experiences are associated with care recipient cognitive performance: Evidence from the National Health and Aging Trends Study and National Study of Caregiving.Frontiers in public health · 2023Article
- Traditional Chinese Medicine for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2022Review
- Toward a broader concept of societal value: family spillovers in Alzheimer's disease.International journal of technology assessment in health care · 2021Article
- Article
- Relation among Caregivers' Burden, Abuse and Behavioural Disorder in People with Dementia.International journal of environmental research and public health · 2021Article
- Efficacy and Safety of DL-3-n-Butylphthalide in the Treatment of Poststroke Cognitive Impairment: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2021Review
- A validation of the Croatian version of Zarit Burden Interview and clinical predictors of caregiver burden in informal caregivers of patients with dementia: a cross-sectional study.Croatian medical journal · 2020Article
- Predictors of caregiver burden in patients with neurologic Wilson disease.The Journal of international medical research · 2020Article
- The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey.Frontiers in aging neuroscience · 2020Article
- Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort.PloS one · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesTo analyse the relationship between caregiver burden and severity of patients' cognitive impairment.
designData were drawn from the cross-sectional 2015/2016 Adelphi Real World Dementia Disease-Specific Programme.
settingThis research was multi-national and studied physicians and their consulting patients with cognitive impairment.
participants1,201 caregivers completed self-assessment forms. MEASUREMENTS: Validated instruments of caregiver wellbeing and burden (EQ-5D-3L questionnaire, EQ-VAS, Zarit Burden Interview, and Work Productivity and Activity Impairment questionnaire) and number of caregiver hours were analysed by severity of patients' cognitive impairment, categorised according to the Mini-Mental State Examination. Data were analysed using Spearman's rank correlation coefficients and ordinary least squares regression models, to compare outcomes between caregivers of patients with prodromal, mild, moderate, and severe dementia.
resultsThe majority of caregivers were female (69.1%), lived with the patient they cared for (75.8%), and only approximately one third (28.3%) were in part- or full-time employment. There were statistically significant (p<0.001) increases in caregiver time (36.9 versus 108.6 hours per week for prodromal versus severe dementia, respectively) and measures of caregiver burden and health status (EQ-5D-3L, EQ-VAS, and Zarit Burden Interview) and increases in measures of work productivity and activity impairment with increasing severity of patients' disease.
conclusionThis study of real-world data confirmed an association between increased caregiver burden and severity of patients' cognitive impairment by analysis of a wide range of validated measures of caregiver burden. These findings suggest that maintaining patients in the earliest stages of their disease for as long as possible may potentially help to protect caregiver wellbeing, although further research is required to confirm this hypothesis.
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