ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
Evidence for functional interactions between the placenta and brain in pregnant mice.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Placental defects revealed by modelling Prader-Willi syndrome in mice.Disease models & mechanisms · 2026Article
- Dietary Carnosic Acid Supplementation Improves the Growth Performance, the Antioxidant Status, and Diversity of Intestinal Microbiota in Broilers.Antioxidants (Basel, Switzerland) · 2025Article
- Maternal-offspring brain and tissue cross-talk in preeclampsia: insights from a rat model.Metabolic brain disease · 2025Article
- Sex-bias metabolism of fetal organs, and their relationship to the regulation of fetal brain-placental axis.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms.BMC medicine · 2024Review
- Article
- Role of caveolin-1 in metabolic programming of fetal brain.iScience · 2023Article
- Associations between prenatal organophosphate pesticide exposure and placental gene networks.Environmental research · 2023Article
- Exposure to two-dimensional ultrathin TiJournal of nanobiotechnology · 2022Article
- Article
- Fetal Brain Elicits Sexually Conflicting Transcriptional Response to the Ablation of Uterine Forkhead Box A2 (International journal of molecular sciences · 2021Article
- Maternal Iron Deficiency Modulates Placental Transcriptome and Proteome in Mid-Gestation of Mouse Pregnancy.The Journal of nutrition · 2021Article
- Characterization of the Primary Human Trophoblast Cell Secretome Using Stable Isotope Labeling With Amino Acids in Cell Culture.Frontiers in cell and developmental biology · 2021Article
- Placental CRH as a Signal of Pregnancy Adversity and Impact on Fetal Neurodevelopment.Frontiers in endocrinology · 2021Review
- Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis.Frontiers in cell and developmental biology · 2021Review
- Sexually dimorphic effects of forkhead box a2 (FOXA2) and uterine glands on decidualization and fetoplacental development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fetal brain and placental programming in maternal obesity: A review of human and animal model studies.Prenatal diagnosis · 2020Review
- Regulation of uterine genes during the peri-implantation period, and its relationship to the maternal brain in gestating mice.Molecular reproduction and development · 2020Article
- Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta-brain axis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy.Pharmacological research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The placenta plays a pivotal role in the development of the fetal brain and also influences maternal brain function, but our understanding of communication between the placenta and brain remains limited. Using a gene expression and network analysis approach, we provide evidence that the placenta transcriptome is tightly interconnected with the maternal brain and fetal brain in d 15 pregnant C57BL/6J mice. Activation of serotonergic synapse signaling and inhibition of neurotrophin signaling were identified as potential mediators of crosstalk between the placenta and maternal brain and fetal brain, respectively. Genes encoding specific receptors and ligands were predicted to affect functional interactions between the placenta and brain. Paralogous genes, such as sex comb on midleg homolog 1/scm-like with 4 mbt domains 2 and polycomb group ring finger (Pcgf) 2/ Pcgf5, displayed antagonistic regulation between the placenta and brain. Additionally, conditional ablation of forkhead box a2 ( Foxa2) in the glands of the uterus altered the transcriptome of the d 15 placenta, which provides novel evidence of crosstalk between the uterine glands and placenta. Furthermore, expression of cathepsin 6 and monocyte to macrophage differentiation associated 2 was significantly different in the fetal brain of Foxa2 conditional knockout mice compared with control mice. These findings provide a better understanding of the intricacies of uterus-placenta-brain interactions during pregnancy and provide a foundation and model system for their exploration.-Behura, S. K., Kelleher, A. M., Spencer, T. E. Evidence for functional interactions between the placenta and brain in pregnant mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.