Evidence map›Paper›PMID 30521316›Full record

ArticleACS combinatorial science2019

Combinatorial Peptide Microarray Synthesis Based on Microfluidic Impact Printing.

Jiannan Li, Siwei Zhao, Gaomai Yang, Ruiwu Liu, Wenwu Xiao, Paolo Disano, Kit S Lam, Tingrui Pan

Open access · greenAbstract read
In one paragraph

Article in ACS combinatorial science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jiannan LiDepartment of Biomedical Engineering , University of California , Davis , California 95616-5270 , United States.ORCID 0000-0002-6089-4785
Siwei ZhaoDepartment of Biomedical Engineering , Tufts University , Boston , Massachusetts 02155 , United States.
Gaomai YangDepartment of Biomedical Engineering , University of California , Davis , California 95616-5270 , United States.
Ruiwu LiuDepartment of Biochemistry and Molecular Medicine , University of California , Davis , California 95817 , United States.
Wenwu XiaoDepartment of Biochemistry and Molecular Medicine , University of California , Davis , California 95817 , United States.
Paolo DisanoDepartment of Biomedical Engineering , University of California , Davis , California 95616-5270 , United States.
Kit S LamDepartment of Biochemistry and Molecular Medicine , University of California , Davis , California 95817 , United States.ORCID 0000-0002-3076-6969
Tingrui PanDepartment of Biomedical Engineering , University of California , Davis , California 95616-5270 , United States.
University of California, Davis · USTufts University · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1M
Digital one-disc-one-compound array for high-throughput discovery of cancer-targeR21CA173243 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PAN, TINGRUI · 2013 to 2015
$644k
NCI NIH HHS P30 CA093373NCI NIH HHS R21 CA173243NIEHS NIH HHS P42 ES004699
6 · The paper itself

Abstract

In this Research Article, a novel inkjet printing technique, micro impact printing (MI printing), is applied for the first time to combinatorial peptide microarray synthesis on amine functionalized microdisc arrays through standard Fmoc chemistry. MI printing shows great advantages in combinatorial peptide microarray synthesis compared with other printing techniques, including (1) a disposable cartridge; (2) a small spot size (80 μm) increases array density; (3) minimal loading volume (0.6 μL) and dead volume (<0.1 μL), reduce chemical waste; and (4) multiplexibility of 5 channels/cartridge and capacity of multiple cartridges. Using this synthesis platform, a tetrapeptide library with 625 permutations was constructed and then applied for the screening of ligands targeting α

Indexed as

AminesCombinatorial Chemistry TechniquesHumansIntegrin alpha4beta1Jurkat CellsMicrofluidic Analytical TechniquesPeptide LibraryPeptidesPrinting, Three-DimensionalProtein Array AnalysisSurface PropertiesAminesIntegrin alpha4beta1Peptide LibraryPeptidescancer targetingintegrin bindingmicrofluidicpeptide microarrayspeptide synthesisprinting

Identifiers

PMID30521316
PMCPMC6335607
OpenAlexW2904480402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.