Evidence map›Paper›PMID 30521161›Full record

ArticleInternational braz j urol : official journal of the Brazilian Society of Urology

Small cell bladder cancer: should we consider prophylactic cranial irradiation?

Tara Nikonow Morgan, Robert M Turner, Julian Baptiste, Timothy D Lyon, Jodi K Maranchie, Ronald L Hrebinko, Benjamin J Davies, Jeffrey R Gingrich, Bruce L Jacobs

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Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tara Nikonow MorganDepartment of Urology, University of Pittsburgh, Pennsylvania, U.S.A.
Robert M TurnerDepartment of Urology, University of Pittsburgh, Pennsylvania, U.S.A.
Julian BaptisteSchool of Medicine, University of Pittsburgh, Pennsylvania, U.S.A.
Timothy D LyonDepartment of Urology, University of Pittsburgh, Pennsylvania, U.S.A.
Jodi K MaranchieDepartment of Urology, University of Pittsburgh, Pennsylvania, U.S.A.
Ronald L HrebinkoDepartment of Urology, University of Pittsburgh, Pennsylvania, U.S.A.
Benjamin J DaviesDepartment of Urology, University of Pittsburgh, Pennsylvania, U.S.A.
Jeffrey R GingrichDepartment of Urology, University of Pittsburgh, Pennsylvania, U.S.A.
Bruce L JacobsDepartment of Urology, University of Pittsburgh, Pennsylvania, U.S.A.
University of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the clinical characteristics, treatment patterns, and outcomes in patients with small cell bladder cancer at our institution, including those who received prophylactic cranial irradiation (PCI) for the prevention of intracranial recurrence. MATERIALS AND

methodsPatients with small cell bladder cancer treated at a single institution between January 1990 and August 2015 were identified and analyzed retrospectively for demographics, tumor stage, treatment, and overall survival.

resultsOf 44 patients diagnosed with small cell bladder cancer, 11 (25%) had metastatic disease at the time of presentation. Treatment included systemic chemotherapy (70%), radical surgery (59%), and local radiation (39%). Six patients (14%) received PCI. Median overall survival was 10 months (IQR 4 - 41). Patients with extensive disease had worse overall survival than those with organ confined disease (8 months vs. 36 months, respectively, p = 0.04). Among those who received PCI, 33% achieved 5 - year survival.

conclusionOutcomes for patients with small cell bladder cancer remain poor. Further research is indicated to determine if PCI increases overall survival in small call bladder cancer patients, especially those with extensive disease who respond to chemotherapy.

Indexed as

Cranial IrradiationAgedAged, 80 and overCarcinoma, Small CellHumansLung NeoplasmsMaleRetrospective StudiesSmall Cell Lung CarcinomaSurvival AnalysisUrinary Bladder NeoplasmsCarcinoma, Small CellProphylactic Surgical ProceduresUrinary Bladder Neoplasms

Identifiers

PMID30521161
PMCPMC6541124
OpenAlexW2945469776

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.