SynthesisJBRA assisted reproduction2019
An update and systematic review on the treatment of primary dysmenorrhea.
Synthesis in JBRA assisted reproduction, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06233786 (Effectiveness of Non-invasive Neuromodulation in Primary Dysmenhorrea), which is not on this map. Cited by 58 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Non-invasive Neuromodulation in Primary Dysmenhorrea: A Randomized Clinical Trial
Who cites it
58 citing papers in PubMed, 7 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Efficacy of non-pharmacological interventions for primary dysmenorrhoea: a systematic review and Bayesian network meta-analysis.BMJ evidence-based medicine · 2024Pooled it
- The Effect of Fenugreek on the Severity of Dysmenorrhea: A Systematic Review and Meta-analysis.Current drug research reviews · 2024Pooled it
- Quality of patient-reported outcome measures for primary dysmenorrhea: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Clinical practice guidelines for endometriosis in Japan (The 3rd edition).The journal of obstetrics and gynaecology research · 2022Guideline
- Safety and efficacy of therapeutic taping in primary dysmenorrhea: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Efficacy of Physiotherapy Treatment in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Fennel for Reducing Pain in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients · 2020Pooled it
- Cai's gynecology cyclical therapy with stasis-clearing and meridian-warming method for primary dysmenorrhea: a randomized controlled trial.Frontiers in endocrinology · 2026Trial
- Integrated Pharmacokinetics, Pharmacodynamics, and Pharmacometabolomics to Elucidate Guizhi Fuling Capsule's Homeostatic Mechanism Against Acute Dysmenorrhea.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Exploring the Nutraceutical Potential ofFood science & nutrition · 2026Review
- Leonurine Exerts an Anti-Primary Dysmenorrhea Effect in Rats by Inactivating the JNK/p38 Pathway.Applied biochemistry and biotechnology · 2026Article
- International Clinical Practice Guidelines on Traditional Chinese Medicine Therapy for Dysmenorrhea: Development Protocol.JMIR research protocols · 2026Article
- Effects of Acupuncture on Uterine Hemodynamics and Early-Phase Pain Relief in Primary Dysmenorrhea: A Retrospective Cohort Study.Journal of pain research · 2026Article
- Article
- Endogenous mediators in regulating primary dysmenorrhea.Frontiers in cell and developmental biology · 2026Review
- Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study.Health science reports · 2026Article
- Holistic approach to dysmenorrhea management: Integrating pharmacological and non-pharmacological interventions for improved women's health in the Middle East and Africa.BMC women's health · 2025Review
- Vitexin as a Potential Antidysmenorrheic Agent: Development of a ZIF-8-Based Immediate-Release System and Evaluation via In Vivo and In Silico Approaches.Biomedicines · 2025Article
- Management practices of primary dysmenorrhea among female high school students in Nekemte town, East Wallaga Zone, Western Oromia, Ethiopia: a cross-sectional study.BMC women's health · 2025Article
- Influence of tobacco smoking and alcohol drinking on dysmenorrhoea: a cross-sectional analysis of data from the Taiwan Biobank.BMJ open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPrimary dysmenorrhea is a painful uterine contraction caused by endometrial laceration. Drug therapies and complementary medicine have been used to treat dysmenorrhea. The aim of this study was to investigate and offer an updated perspective on the treatments for dysmenorrhea.
methodsThe present study was conducted in accordance with the PRISMA checklist for systematic reviews and meta-analyses. The required information was collected based on searches for the following keywords: treatment, primary dysmenorrhea, medicinal plants, chemical drugs, and herbs. Searches were performed on databases Pubmed, Web of Sciences, Scopus, Iran medex, and SID by March 2018 to find literature in the English and Persian languages on this subject without a time limit.
resultsThis review included 17 papers, 10 of which on complementary medicine, three on drug therapies, and four on acupuncture and acupressure. The largest and smallest samples had 303 and 24 patients, respectively. Length of treatment ranged from one to six months and the measures most commonly used in the studies were the visual analogue scale and clinical efficacy. Reported complications included gastrointestinal events, nausea, vomiting, diarrhea, abdominal pain, and liver and kidney disorders.
conclusionMedicinal plants, drugs, and acupressure seem to suppress pain by reducing the level of prostaglandins, mediating nitric oxide, increasing beta-endorphin levels, blocking the calcium channel, and enhancing circulatory flow through the uterine pathway. Further trials are required to confirm the benefits of the procedures described and ensure the absence of complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.