Evidence map›Paper›PMID 30521149›Full record

ArticleThe breast journal2019

Breast implant-associated anaplastic large cell lymphoma: Clinical and imaging findings at a large US cancer center.

Brittany Z Dashevsky, Katherine M Gallagher, Anne Grabenstetter, Peter G Cordeiro, Ahmet Dogan, Elizabeth A Morris, Steven M Horwitz, Elizabeth J Sutton

Open access · greenAbstract read
In one paragraph

Article in The breast journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brittany Z DashevskyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York.ORCID 0000-0002-0545-5165
Katherine M GallagherDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York.
Anne GrabenstetterDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York City, New York.
Peter G CordeiroDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York.
Ahmet DoganDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York City, New York.
Elizabeth A MorrisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York.
Steven M HorwitzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York.
Elizabeth J SuttonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeEvaluate the clinical presentation and imaging findings of breast implant-associated anaplastic large cell lymphoma (BIA ALCL) at a large US cancer center. MATERIALS AND

methodsHIPAA-compliant IRB approved retrospective study, for which informed consent was waived. The Hospital Information System was screened for women who underwent implant reconstruction and were diagnosed with BIA ALCL between 2010 and 2016. Two radiologists reviewed images in consensus. Clinical and imaging characteristics were summarized using means and ranges for continuous variables and percentages for categorical variables.

resultsPatient cohort included 11 women with BIA ALCL (mean age at diagnosis = 54 years, range: 35-77), including women with (9/11) and without (2/11) history of breast cancer. Mean time from breast implant placement to diagnosis was 10 years (range: 6-14). BIA ALCL was identified in patients with saline (4/11) and silicone (5/11) implants. Implants were textured in 7/11 (63%) and unknown in 4/11 (36%) cases. All patients presented with a peri-implant seroma, (9/11 documented on imaging). Two of 11 patients had a mass within this seroma. Ten of 11 patients (91%) presented with symptoms.

conclusionsSaline and silicone breast implants may predispose patients to a rare lymphoma subtype, BIA ALCL, which presents on imaging as a peri-implant fluid collection ± mass.

Indexed as

AdultAgedBiopsy, Fine-NeedleBreast ImplantationBreast ImplantsBreast NeoplasmsFemaleHumansLymphoma, Large-Cell, AnaplasticMagnetic Resonance ImagingMammaplastyMiddle AgedTime FactorsUltrasonography, Mammary

Identifiers

PMID30521149
PMCPMC12036945
OpenAlexW2904515446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.