Evidence map›Paper›PMID 30521138›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019

Mapping Aldehyde Dehydrogenase 1A1 Activity using an [

Raul Pereira, Thibault Gendron, Chandan Sanghera, Hannah E Greenwood, Joseph Newcombe, Patrick N McCormick, Kerstin Sander, Maya Topf, Erik Årstad, Timothy H Witney

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Molecular Imaging of Cancer Stem Cells and Their Role in Therapy Resistance.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  2. Article
  3. A prodrug strategy for theRSC chemical biology · 2022
    Article
  4. Latest Advances in Imaging Oxidative Stress in Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Review
  5. Mapping Aldehyde Dehydrogenase 1A1 Activity using an [Chemistry (Weinheim an der Bergstrasse, Germany) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Raul PereiraCentre for Advanced Biomedical Imaging, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Thibault GendronDepartment of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Chandan SangheraCentre for Advanced Biomedical Imaging, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Hannah E GreenwoodCentre for Advanced Biomedical Imaging, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Joseph NewcombeDepartment of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Patrick N McCormickCentre for Advanced Biomedical Imaging, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Kerstin SanderDepartment of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Maya TopfDepartment of Biological Sciences, Birkbeck, University of London, Malet Street, London, WC1E 7HX, UK.
Erik ÅrstadDepartment of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Timothy H WitneyCentre for Advanced Biomedical Imaging, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.ORCID http://orcid.org/0000-0002-9475-2873
St Thomas' Hospital · GBUniversity College London · GBBirkbeck, University of London · GB

Funding

Cancer Research UK C1519/A16463Engineering and Physical Sciences Research Council C1519/A16463The Royal Society 107610/Z/15/ZWellcome Trust 107610Wellcome Trust 107610/Z/15/Z
6 · The paper itself

Abstract

Aldehyde dehydrogenases (ALDHs) catalyze the oxidation of aldehydes to carboxylic acids. Elevated ALDH expression in human cancers is linked to metastases and poor overall survival. Despite ALDH being a poor prognostic factor, the non-invasive assessment of ALDH activity in vivo has not been possible due to a lack of sensitive and translational imaging agents. Presented in this report are the synthesis and biological evaluation of ALDH1A1-selective chemical probes composed of an aromatic aldehyde derived from N,N-diethylamino benzaldehyde (DEAB) linked to a fluorinated pyridine ring either via an amide or amine linkage. Of the focused library of compounds evaluated, N-ethyl-6-(fluoro)-N-(4-formylbenzyl)nicotinamide 4 b was found to have excellent affinity and isozyme selectivity for ALDH1A1 in vitro. Following

Indexed as

Aldehyde DehydrogenaseAnimalsBiocatalysisEnzyme ActivationFluorine RadioisotopesLiverLungMiceOxidation-ReductionPositron-Emission TomographySubstrate SpecificityAldehyde DehydrogenaseFluorine-18Fluorine Radioisotopes[18F]fluorinationaldehyde dehydrogenasecancerradiochemistryradiolabeling

Identifiers

PMID30521138
PMCPMC6379060
OpenAlexW2903865647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.