Evidence map›Paper›PMID 30521066›Full record

ArticleInternational journal of cancer2019

Mediation of associations between adiposity and colorectal cancer risk by inflammatory and metabolic biomarkers.

Joshua Petimar, Fred K Tabung, Linda Valeri, Bernard Rosner, Andrew T Chan, Stephanie A Smith-Warner, Edward L Giovannucci

Open access · bronzeAbstract read
In one paragraph

Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Correcting for bias due to mismeasured exposure in mediation analysis with a survival outcome.Journal of the Royal Statistical Society. Series C, Applied statistics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joshua PetimarDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0002-3025-5931
Fred K TabungDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0001-8193-7150
Linda ValeriDepartment of Psychiatry, Harvard Medical School, Boston, MA.
Bernard RosnerDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0001-6907-0056
Andrew T ChanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Stephanie A Smith-WarnerDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Edward L GiovannucciDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Harvard University · USBrigham and Women's Hospital · US

Funding

Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SPIEGELMAN, DONNA L · 1991 to 2009
$41.8M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
CVD Epidemiology Training Program in Behavior, the Environment and Global HealthT32HL098048 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Goodarz Danaei, ERIC B RIMM · 2009 to 2026
$6.9M
Proinflammatory and hyperinsulinemic dietary patterns and colorectal cancer risk: role of the metabolomeK99CA207736 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TABUNG, FRED KINYUY · 2016 to 2017
$276k
NCI NIH HHS K99 CA207736NCI NIH HHS P01 CA055075NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA167552NHLBI NIH HHS T32 HL098048
6 · The paper itself

Abstract

Inflammation and hyperinsulinemia may drive associations between adiposity and colorectal cancer (CRC) risk, but few studies have examined this hypothesis using mediation analysis. We used inverse odds ratio weighting and logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for estimated total effects (OR

Indexed as

AdiposityAgedBiomarkersBiomarkers, TumorBody Mass IndexCase-Control StudiesColorectal NeoplasmsHumansInflammationLogistic ModelsMaleMiddle AgedOdds RatioUnited StatesBiomarkersBiomarkers, Tumoradipositycolorectal cancerinflammatory biomarkersmediation analysismetabolic biomarkers

Identifiers

PMID30521066
PMCPMC6462234
OpenAlexW2904177873

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.