ArticleThe American journal of pathology1988
Streptococcal cell wall-induced arthritis and flare-up reaction in mice induced by homologous or heterologous cell walls.
Article in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria.Malaria journal · 2023Article
- Innate Immunity and Sex: Distinct Inflammatory Profiles Associated with Murine Pain in Acute Synovitis.Cells · 2023Article
- Local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis.Scientific reports · 2022Article
- Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently reduces experimental arthritis in mice.Rheumatology (Oxford, England) · 2021Article
- The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis.Arthritis research & therapy · 2020Article
- Dynamic transcriptome analysis unveils key proresolving factors of chronic inflammatory arthritis.The Journal of clinical investigation · 2020Article
- Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.Rheumatology (Oxford, England) · 2016Article
- Arthritis susceptibility and the gut microbiome.FEBS letters · 2014Review
- IL-17 producing T cells in mouse models of multiple sclerosis and rheumatoid arthritis.Journal of molecular medicine (Berlin, Germany) · 2012Review
- A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis.Arthritis research & therapy · 2010Article
- Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.Arthritis and rheumatism · 2009Article
- BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.Arthritis research & therapy · 2009Article
- Lessons from animal models of arthritis over the past decade.Arthritis research & therapy · 2009Review
- GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice.Annals of the rheumatic diseases · 2007Article
- An inflammation-inducible adenoviral expression system for local treatment of the arthritic joint.Gene therapy · 2004Article
- Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice.Gene therapy · 2003Article
- A tropism-modified adenoviral vector increased the effectiveness of gene therapy for arthritis.Gene therapy · 2001Article
- Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw.Clinical and experimental immunology · 2000Article
- Blockade of endogenous interleukin 12 results in suppression of murine streptococcal cell wall arthritis by enhancement of interleukin 10 and interleukin 1Ra.Annals of the rheumatic diseases · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intra-articular injection of cell walls from the gram-positive bacterium Streptococcus pyogenes induces an arthritis in both streptococcal cell wall (SCW)-primed and naive mice. This joint inflammation subsides after 2 weeks but it could be reactivated by systemic injection of SCW in a dose-dependent way. The primary arthritis as well as the flare-up reaction were more vehement in immunized than naive mice. Pretreatment with antilymphocyte serum of nonimmunized arthritic mice before systemic challenge completely inhibits the flare-up reaction, suggesting the involvement of lymphocytes in the reactivation. Dose-response studies showed that intravenous challenge with SCW amounts too small to induce a primary arthritis were able to reactivate a chronic arthritis, implying that an inflamed joint is in a hyperreactive state, probably due to locally retained lymphocytes. Arthritis as a result of injection with SCW can be reactivated by fragments of a nonrelated, gram negative endogenous bacterium, Escherichia coli. The latter finding might be of importance for the understanding of the pathogenesis of chronic arthritis: once an arthritis is induced by one bacterium, other (unrelated) bacteria, probably derived from an endogenous source, may be able to reactivate the inflammatory process, thus contributing to chronicity.
Indexed as
Identifiers
3052092PMC1880648W1820773886What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.