ArticleeLife2018
A secretory pathway kinase regulates sarcoplasmic reticulum Ca
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Application of acute myocardial infarction-related key genes in noninvasive diagnosis: a comprehensive analysis based on transcriptome and single-cell transcriptome.Frontiers in genetics · 2026Article
- Comprehensive Analysis of the Putative Substratome of FAM20C, the Master Serine Kinase of the Secretory Pathway.Biomolecules · 2025Article
- Protein kinase FAM20C-when subcellular localization matters.FEBS letters · 2025Review
- NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization.Nature communications · 2025Article
- FAM20C: A key protein kinase in multiple diseases.Genes & diseases · 2025Review
- Proteomic insights into the extracellular matrix: a focus on proteoforms and their implications in health and disease.Expert review of proteomics · 2024Review
- Gingival proteomics reveals the role of TGF beta and YAP/TAZ signaling in Raine syndrome fibrosis.Scientific reports · 2024Article
- The Structural-Functional Crosstalk of the Calsequestrin System: Insights and Pathological Implications.Biomolecules · 2023Review
- Passing the post: roles of posttranslational modifications in the form and function of extracellular matrix.American journal of physiology. Cell physiology · 2023Review
- The function and regulation of calsequestrin-2: implications in calcium-mediated arrhythmias.Biophysical reviews · 2022Review
- Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy.International journal of molecular sciences · 2022Article
- STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases.Frontiers in aging · 2022Review
- Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Fam20C in Human Diseases: Emerging Biological Functions and Therapeutic Implications.Frontiers in molecular biosciences · 2021Review
- Homozygous G650del nexilin variant causes cardiomyopathy in mice.JCI insight · 2020Article
- Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes.Circulation. Heart failure · 2020Article
- Characterization of Signaling Pathways Associated with Pancreatic β-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes inMolecular & cellular proteomics : MCP · 2020Article
- Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.The EMBO journal · 2020Article
- Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals.IUBMB life · 2019Review
- Taurine AttenuatesFrontiers in immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Adam J PollakDepartment of Pharmacology, University of California, San Diego, San Diego, United States.ORCID http://orcid.org/0000-0001-5266-4691
Canzhao LiuDepartment of Medicine, University of California, San Diego, San Diego, United States.
Aparna GudlurDivision of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, San Diego, United States.
Joshua E MayfieldDepartment of Pharmacology, University of California, San Diego, San Diego, United States.
Nancy D DaltonDepartment of Medicine, University of California, San Diego, San Diego, United States.
Yusu GuDepartment of Medicine, University of California, San Diego, San Diego, United States.
Ju ChenDepartment of Medicine, University of California, San Diego, San Diego, United States.
Joan Heller BrownDepartment of Pharmacology, University of California, San Diego, San Diego, United States.
Patrick G HoganDivision of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, San Diego, United States.
Sandra E WileyDepartment of Pharmacology, University of California, San Diego, San Diego, United States.
Kirk L PetersonDepartment of Medicine, University of California, San Diego, San Diego, United States.
Jack E DixonDepartment of Pharmacology, University of California, San Diego, San Diego, United States.ORCID http://orcid.org/0000-0002-8266-5449
University of California San Diego · USLa Jolla Institute for Immunology · US
Funding
SIGNAL TRANSDUCTION AND GENE INDUCTION IN T LYMPHOCYTESR01AI040127 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, RAO, ANJANA · 1996 to 2025
$13.3MContemporary Approaches to Cancer Cell Signaling and CommunicationT32CA009523 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DONOGHUE, DANIEL J, YANG, JING · 1985 to 2025
$12.1MTraining In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MNFAT, bZIP proteins, and transcriptional programs in lymphocytesR01AI109842 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Patrick Hogan, Anjana Rao · 2014 to 2026
$8.6MREGULATION OF NEUROPEPTIDE BIOSYNTHESISR01DK018849 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIXON, JACK E, WORBY, CAROLYN ANN · 1986 to 2020
$7.0MSTUDIES ON PANCREATIC HORMONESR37DK018024 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIXON, JACK E · 1988 to 2013
$5.6MSTIM-ORAI signaling and other calcium influx pathways in lymphocytesR01AI084167 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK · 2009 to 2019
$4.9MRhoA mediated survival signals in cardiomyocytesR37HL028143 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER · 2010 to 2019
$4.0MSTUDIES ON PANCREATIC HORMONESR01DK018024 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIXON, JACK E, WORBY, CAROLYN ANN · 1986 to 2018
$2.1MALPK3 in cardiac function and diseaseR01HL146759 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2019 to 2022
$1.6MCardiomyocyte CaM kinase II as a driver of cardiac inflammation and remodelingR01HL145459 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, MIYAMOTO, SHIGEKI · 2019 to 2022
$1.6MThe role of Nexilin in cardiomyocyte and cardiomyopathyR01HL137957 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2017 to 2020
$1.6MNCI NIH HHS T32 CA009523NHLBI NIH HHS F32 HL136122NHLBI NIH HHS R01 HL137957NHLBI NIH HHS R01 HL145459NHLBI NIH HHS R01 HL146759NHLBI NIH HHS R37 HL028143NHLBI NIH HHS T32 HL007444NIAID NIH HHS R01 AI040127NIAID NIH HHS R01 AI084167NIAID NIH HHS R01 AI109842NIAID NIH HHS R56 AI109842NIDDK NIH HHS R01 DK018024NIDDK NIH HHS R01 DK018849NIDDK NIH HHS R37 DK018024NIGMS NIH HHS R01 GM065490NIH HHS 3T32HL007444-34S1NIH HHS 5T32CA009523-32NIH HHS AI040127NIH HHS AI109842NIH HHS DK018024-43NIH HHS DK018849-41NIH HHS F32HL136122NIH HHS R37HL028143
Abstract
Ca
Indexed as
AnimalsCalciumCalcium-Binding ProteinsCalcium SignalingCalsequestrinEndoplasmic ReticulumExtracellular Matrix ProteinsHeart FailureHomeostasisHumansMiceMyocytes, CardiacPhosphorylationPhosphotransferasesSarcoplasmic ReticulumSecretory PathwayCalciumCalcium-Binding ProteinsCalsequestrincasq2 protein, mouseExtracellular Matrix ProteinsFAM20C protein, mousePhosphotransferasesStim1 protein, mouseStromal Interaction Molecule 1biochemistrycalciumcalsequestrin 2chemical biologyheart diseasemouseprotein kinaseStim 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.