Evidence map›Paper›PMID 30520704›Full record

ArticleRadiation research2019

Effects of High- and Low-LET Radiation on Human Hematopoietic System Reconstituted in Immunodeficient Mice.

Daniela Hoehn, Monica Pujol-Canadell, Erik F Young, Geo Serban, Igor Shuryak, Jennifer Maerki, Zheng Xu, Mashkura Chowdhury, Aesis M Luna, George Vlada and 1 more

Open access · greenAbstract read
In one paragraph

Article in Radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome.International journal of molecular sciences · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Daniela Hoehna Columbia University Medical Center, New York, New York.
Monica Pujol-Canadella Columbia University Medical Center, New York, New York.
Erik F Younga Columbia University Medical Center, New York, New York.
Geo Serbana Columbia University Medical Center, New York, New York.
Igor Shuryaka Columbia University Medical Center, New York, New York.
Jennifer Maerkib Northwell Health, New Hyde Park, New York.
Zheng Xua Columbia University Medical Center, New York, New York.
Mashkura Chowdhurya Columbia University Medical Center, New York, New York.
Aesis M Lunaa Columbia University Medical Center, New York, New York.
George Vladaa Columbia University Medical Center, New York, New York.
Lubomir B Smilenova Columbia University Medical Center, New York, New York.
Columbia University Irving Medical Center · USNorthwell Health · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3M
Sample Engineering CoreU19AI067773 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FORNACE, ALBERT J · 2005 to 2024
$105.4M
Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
NCI NIH HHS P30 CA013696NIAID NIH HHS U19 AI067773NIAID NIH HHS U19 AI067798NIH HHS P30CA013696NIH HHS U19 AI067773NIH HHS U19 AI AI67798
6 · The paper itself

Abstract

Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that may be induced by high-energy galactic cosmic rays encountered on interplanetary space missions. To collect data on the effects of space radiation on the human hematopoietic system in vivo, we used a humanized mouse model. In this study, we irradiated humanized mice with 0.4 Gy of 350 MeV/n

Indexed as

Cosmic RadiationAnimalsBlood Cell CountBone MarrowDose-Response Relationship, RadiationHematopoiesisHematopoietic Stem CellsHumansMiceMice, Inbred NODModels, AnimalNeoplasms, Radiation-InducedRelative Biological EffectivenessSpace FlightSpleen

Identifiers

PMID30520704
PMCPMC6555159
OpenAlexW2903494583

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.