Evidence map›Paper›PMID 30520689›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.

C Zhang, C Ramsey, A Berical, L Yu, L Leng, K A McGinnis, Y Song, H Michael, M C McCormack, H Allore and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

C ZhangDepartment of Medicine Saint Louis University Hospital , Saint Louis, Missouri.
C RamseyYale Center for Medical Informatics, Yale School of Medicine , New Haven, Connecticut.
A BericalDepartment of Medicine, Boston University School of Medicine , Boston, Massachusetts.
L YuDepartment of Medicine, Massachusetts General Hospital , Boston, Massachusetts.
L LengDepartment of Medicine, Yale School of Medicine , New Haven, Connecticut.
K A McGinnisVeterans Affairs Connecticut Healthcare System, West Haven, Connecticut.
Y SongDepartment of Medicine, Yale School of Medicine , New Haven, Connecticut.
H MichaelDepartment of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
M C McCormackDepartment of Medicine, Johns Hopkins University , Baltimore, Maryland.
H AlloreDepartment of Medicine, Yale School of Medicine , New Haven, Connecticut.
A MorrisDepartment of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
K CrothersDepartment of Medicine, University of Washington School of Medicine , Seattle, Washington.
R BucalaDepartment of Medicine, Yale School of Medicine , New Haven, Connecticut.
P J LeeDepartment of Medicine, Yale School of Medicine , New Haven, Connecticut.
M SaulerDepartment of Medicine, Yale School of Medicine , New Haven, Connecticut.ORCID 0000-0001-5240-7978
Yale University · USUniversity of Pittsburgh · USJohns Hopkins University · USMassachusetts General Hospital · USSaint Louis University Hospital · USUniversity of Washington · USVA Connecticut Healthcare System · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Mechanisms of Rheumatoid Synovial Fibroblast ActivationR01AR049610 · NIAMS · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2002 to 2018
$5.0M
Longitudinal Studies of HIV-Associated Lung Infections and ComplicationsR01HL090342 · NHLBI · YALE UNIVERSITY · PI CROTHERS, KRISTINA ANNE · 2007 to 2011
$4.0M
Translational evaluation of aging, inflammation, and HIV in lung dysfunctionR01HL120398 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORRIS, ALISON · 2013 to 2017
$3.4M
Longitudinal evaluation of HIV-associated lung disease phenotypesR01HL125049 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MELLORS, JOHN W, MORRIS, ALISON · 2014 to 2017
$3.3M
HIV and Emphysema _ Role of Pulmonary Vascular DysfunctionR01HL126536 · NHLBI · UNIVERSITY OF WASHINGTON · PI CROTHERS, KRISTINA ANNE, SCHNAPP, LYNN M · 2014 to 2018
$2.8M
Tie Tek Modulation of Cardiac DevelopmentR01HL118386 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BALDWIN, H SCOTT · 2013 to 2017
$2.1M
Aging and Innate Immune Mechanisms in Pulmonary InfectionR01HL130669 · NHLBI · YALE UNIVERSITY · PI BUCALA, RICHARD J, GOLDSTEIN, DANIEL ROBERT · 2015 to 2018
$1.7M
TLR4-MEDIATED EPIGENETIC AND SENESCENCE MECHANISMS IN EMPHYSEMAR01HL138396 · NHLBI · YALE UNIVERSITY · PI LEE, PATTY J · 2017 to 2020
$1.5M
BLRD VA I01 BX003265NCATS NIH HHS UL1 TR001857NHLBI NIH HHS K08 HL135402NHLBI NIH HHS K24 HL123342NHLBI NIH HHS R01 HL090342NHLBI NIH HHS R01 HL118386NHLBI NIH HHS R01 HL120398NHLBI NIH HHS R01 HL125049NHLBI NIH HHS R01 HL126536NHLBI NIH HHS R01 HL130669NHLBI NIH HHS R01 HL138396NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIAMS NIH HHS R01 AR049610NIA NIH HHS P30 AG021342
6 · The paper itself

Abstract

Cigarette smoke exposure is the leading modifiable risk factor for chronic obstructive pulmonary disease (COPD); however, the clinical and pathologic consequences of chronic cigarette smoke exposure are variable among smokers. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of COPD. Within the promoter of the MIF gene is a functional polymorphism that regulates MIF expression (-794 CATT

Indexed as

Forced Expiratory VolumeGenetic Predisposition to DiseaseLungMacrophage Migration-Inhibitory FactorsPolymorphism, Single NucleotidePromoter Regions, GeneticPulmonary Disease, Chronic ObstructiveRespiratory Function TestsSmokeVital CapacityMacrophage Migration-Inhibitory FactorsSmokeCOPDdiffusion capacityemphysemamacrophage migration inhibitory factorMIF

Identifiers

PMID30520689
PMCPMC6397351
OpenAlexW2905283449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.