ArticleJournal of the American Heart Association2018
Cardiovascular Risk Factors and Brain Health: Impact on Long-Range Cortical Connections and Cognitive Performance.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Language Recovery after Brain Injury: A Structural Network Control Theory Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Trial
- Reduced structural connectivity in age-related hearing loss aligns with the sensory deprivation theory.GeroScience · 2026Article
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- The relationship between racial discrimination and white matter among Black older adults.Neurobiology of aging · 2025Article
- Identifying links between cardiovascular disease and insomnia by modeling genes from a pleiotropic locus.Disease models & mechanisms · 2025Article
- Exploring the Association Between Myocardial Infarction and Cognitive Decline: A Narrative Review.Cureus · 2025Review
- Association between large neutral amino acids and white matter hyperintensities in middle-aged adults at varying metabolic risk.Brain imaging and behavior · 2024Article
- Article
- Long-range white matter fibres and post-stroke verbal and non-verbal cognition.Brain communications · 2024Article
- Dynamic network properties of the superior temporal gyrus mediate the impact of brain age gap on chronic aphasia severity.Communications biology · 2023Article
- Mania-related effects on structural brain changes in bipolar disorder - a narrative review of the evidence.Molecular psychiatry · 2023Review
- Diabetes, brain health, and treatment gains in post-stroke aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The role of population-level preventive care for brain health in ageing.The lancet. Healthy longevity · 2023Review
- Small Vessel Disease, a Marker of Brain Health: What the Radiologist Needs to Know.AJNR. American journal of neuroradiology · 2022Review
- Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2022Article
- High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy.NeuroImage · 2022Article
- Integrating multiple brain imaging modalities does not boost prediction of subclinical atherosclerosis in midlife adults.NeuroImage. Clinical · 2022Article
- Association between metabolic syndrome and resting-state functional brain connectivity.Neurobiology of aging · 2021Article
- Ten things to know about ten imaging studies: A preventive cardiology perspective ("ASPC top ten imaging").American journal of preventive cardiology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Background Cardiovascular risk factor burden in the absence of clinical or radiological "events" is associated with mild cognitive impairment. Magnetic resonance imaging techniques exploring the integrity of neuronal fiber connectivity within white matter networks supporting cognitive processing could be used to measure the impact of cardiovascular disease on brain health and be used beyond bedside neuropsychological tests to detect subclinical changes and select or stratify participants for entry into clinical trials. Methods and Results We assessed the relationship between verbal IQ and brain network integrity and the effect of cardiovascular risk factors on network integrity by constructing whole-brain structural connectomes from magnetic resonance imaging diffusion images (N=60) from people with various degrees of cardiovascular risk factor burden. We measured axonal integrity by calculating network density and determined the effect of fiber loss on network topology and efficiency, using graph theory. Multivariate analyses were used to evaluate the relationship between cardiovascular risk factor burden, physical activity, age, education, white matter integrity, and verbal IQ . Reduced network density, resulting from a disproportionate loss of long-range white matter fibers, was associated with white matter network fragmentation ( r=-0.52, P<10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.