Antibacterial Activity of 2-(3',5'-Dibromo-2'-methoxyphenoxy)-3,5- dibromophenol Isolated from Phyllospongia papyracea.

Shi Sun, Corene Canning, Kuiwu Wang, Wenjun Zhu, Fei Yang, Yifan Zhang, Kequan Zhou

Abstract read

In one paragraph

Article in Natural product communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Seasonal Variation in Antimicrobial Activity of Crude Extracts ofInternational journal of microbiology · 2021
Article
Deacetylphylloketal, a New Phylloketal Derivative from a Marine Sponge, GenusMarine drugs · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shi Sun

Corene Canning

Kuiwu Wang

Wenjun Zhu

Fei Yang

Yifan Zhang

Kequan Zhou

Funding

Novel action of grape skin components on postprandial hyperglycemiaR01AT007566 · NCCIH · WAYNE STATE UNIVERSITY · PI ZHOU, KEQUAN · 2013 to 2017

$2.1M

NCCIH NIH HHS R01 AT007566

6 · The paper itself

Abstract

A principal active antimicrobial compound, 2-(3',5'-dibromo-2'-methoxyphenoxy)-3,5-dibromophenol, was isolated from the methanol extract of Phyllospongiapapyracea via bioassay-guided fractionation and isolation. The crude extract and the purified compound were assayed to determine the minimal - inhibitory concentration and minimal bactericidal concentration (MBC) using the broth. microdilution method. The purified compound was found to be highly active against Bacillus subtilis and Staphylococcus aureus at MIC=1 μg/mL, Campylobacter jejuni at MIC=2 gg/mL, Pseudomonas aeruginosa at MIC=4 μg/mL; and Streptococcus pneumoniae and Listeria monocytogenes at MIC = 8 μg/mL. The activity of this compound was found to be comparable with antibiotics commonly used to control these species of bacteria. The results establish 2-(3',5'-dibromo-2'-methoxyphenoxy)-3,5-dibromopheno as a potential lead molecule for the development of antibacterial agents.

Indexed as

AnimalsAnti-Bacterial AgentsBacillus subtilisMicrobial Sensitivity TestsMolecular StructurePhenolsPoriferaPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsPhenols

Identifiers

PMID30520598

PMCPMC6291838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.