Evidence map›Paper›PMID 30520523›Full record

ArticleJournal of veterinary internal medicine2019

Allergen-specific immunoglobulin E in sera of horses affected with insect bite hypersensitivity, severe equine asthma or both conditions.

Maëva Verdon, Simone Lanz, Claudio Rhyner, Vinzenz Gerber, Eliane Marti

Abstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Frontiers in immunology · 2024
    Article
  5. Decision Making in Severe Equine Asthma-Diagnosis and Monitoring.Animals : an open access journal from MDPI · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maëva VerdonEquine clinic, Swiss Institute of Equine Medicine, University of Bern and Agroscope, Berne, Switzerland.ORCID https://orcid.org/0000-0001-7950-1331
Simone LanzEquine clinic, Swiss Institute of Equine Medicine, University of Bern and Agroscope, Berne, Switzerland.ORCID https://orcid.org/0000-0003-2453-1829
Claudio RhynerDepartment of Vaccine Development, Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland.ORCID https://orcid.org/0000-0002-7557-9171
Vinzenz GerberEquine clinic, Swiss Institute of Equine Medicine, University of Bern and Agroscope, Berne, Switzerland.ORCID https://orcid.org/0000-0002-7834-4482
Eliane MartiDepartment of Clinical Research, University of Bern, Berne, Switzerland.ORCID https://orcid.org/0000-0003-1284-4350

Funding

Institut Suisse de Médecine Équine Account : 39-890Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 131003A162548/1Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030-160196 and
6 · The paper itself

Abstract

backgroundGenetic, epidemiologic, and clinical evidence suggests that, in horses, there are manifestations of hypersensitivity that can occur together.

objectivesTo investigate whether concurrent insect bite hypersensitivity (IBH) and severe equine asthma (EA) is associated with higher allergen-specific and total serum immunoglobulin E (IgE) concentrations than only EA or IBH. ANIMALS: Healthy control horses (C, n = 40), horses with IBH (IBH, n = 24), severe EA (EA, n = 18), and both conditions (IBH/EA, n = 23) were included.

methodsIn our retrospective comparative study, sera from horses with signs of severe EA, IBH, and control animals were used. IgE specific for 15 recombinant (r) allergens as well as total serum IgE concentrations were measured by enzyme-linked immunosorbent assay.

resultsGroup IBH (median sum r-Culicoides IgE: optical density at 405 nm [OD CONCLUSIONS AND CLINICAL IMPORTANCE: Susceptibility of IBH-affected horses to develop EA is likely not associated with IgE-mediated immune reactions but with other immunopathological mechanisms.

Indexed as

AllergensAnimalsAsthmaCase-Control StudiesCeratopogonidaeFemaleHorse DiseasesHorsesHypersensitivityImmunoglobulin EInsect Bites and StingsMaleRetrospective StudiesAllergensImmunoglobulin Eequine asthmahorseimmunoglobulin Einsect bite hypersensitivitymultiple equine allergies

Identifiers

PMID30520523
PMCPMC6335542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.