ArticlePest management science2019
Metyltetraprole, a novel putative complex III inhibitor, targets known QoI-resistant strains of Zymoseptoria tritici and Pyrenophora teres.
Article in Pest management science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- FM-3224: A potent triazolinone-based fungicide with broad-spectrum activity and computational support for putative dual-target binding.Pest management science · 2026Article
- Heterocyclic-Based Fungicides: Emerging Strategies for Viable Plant Disease Control.Chemistry & biodiversity · 2026Review
- Toxicity Assessment of Metyltetraprole, a Novel Fungicide Inhibitor, to Embryo/Larval Zebrafish (Toxics · 2025Article
- Status of Fungicide Resistance and Physiological Characterization of Tebuconazole Resistance inCurrent issues in molecular biology · 2022Article
- Latest Research Trends in Agrochemical Fungicides: Any Learnings for Pharmaceutical Antifungals?ACS medicinal chemistry letters · 2022Article
- Synthesis of potent antifungal 3,4-dichloroisothiazole-based strobilurins with both direct fungicidal activity and systemic acquired resistance.RSC medicinal chemistry · 2022Article
- Search for Novel Lead Inhibitors of Yeast Cytochrome bc1, from Drugbank and COCONUT.Molecules (Basel, Switzerland) · 2021Article
- Structural Investigation and Molecular Modeling Studies of Strobilurin-Based Fungicides Active against the Rice Blast PathogenInternational journal of molecular sciences · 2021Article
- Microtiter plate test using liquid medium is an alternative method for monitoring metyltetraprole sensitivity in Cercospora beticola.Pest management science · 2021Article
- Review
- Antifungal activity of metyltetraprole against the existing QoI-resistant isolates of various plant pathogenic fungi: Metyltetraprole against QoI-R isolates.Pest management science · 2020Article
- Article
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3 authors.
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Abstract
backgroundMetyltetraprole is a new fungicide with a unique tetrazolinone-moiety and a similar side chain to a known quinone outside inhibitor (QoI), pyraclostrobin. In this study we describe a unique bioactivity of metyltetraprole on QoI-resistant strains of Zymoseptoria tritici and Pyrenophora teres.
resultsMetyltetraprole exhibited potent antifungal activity against Ascomycetes; it was especially effective against Z. tritici and P. teres in seedling pot tests. Metyltetraprole was also effective in field tests with QoI-resistant mutants. Antifungal activity tests using field strains of Z. tritici and P. teres showed that the performance of metyltetraprole was unaltered by QoI, succinate dehydrogenase inhibitor (SDHI), and sterol 14α-demethylation inhibitor (DMI) resistance. However, the mitochondrial activity test indicated that the compound inhibits the respiratory chain via complex III.
conclusionMetyltetraprole is a novel fungicide that is highly effective against a wide range of fungal diseases, including important cereal diseases. Although metyltetraprole most likely inhibits the respiratory chain via complex III, it remains effective against QoI resistant strains. Therefore, metyltetraprole is considered as a novel fungicidal agent for controlling diseases affecting cereal crops and overcoming pathogen resistance to existing fungicides. © 2018 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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