ArticleJournal of veterinary internal medicine2019
Viral testing of 18 consecutive cases of equine serum hepatitis: A prospective study (2014-2018).
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- A pegivirus associated with encephalitis in red-legged partridges shows neurotropism across avian species.Nature communications · 2026Article
- Molecular prevalence of equine parvovirus hepatitis in healthy horses from the Northern region of the state of Rio Grande do Sul, Brazil.Veterinary research communications · 2026Article
- Article
- First detection of equine hepacivirus RNA in Stomoxys calcitrans (Diptera, Muscidae) in eastern Austria.BMC veterinary research · 2025Article
- Article
- Article
- Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia.Viruses · 2024Article
- Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses.Veterinary pathology · 2024Article
- Article
- Prevalence of equine parvovirus-hepatitis in healthy broodmares in Ontario, Canada.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Prevalence and pathology of equine parvovirus-hepatitis in racehorses from New York racetracks.Virology journal · 2022Article
- TLR-activated mesenchymal stromal cell therapy and antibiotics to treat multi-drug resistantAnnals of translational medicine · 2022Article
- Nasal transmission of equine parvovirus hepatitis.Journal of veterinary internal medicine · 2022Article
- Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update.Animals : an open access journal from MDPI · 2022Review
- Active equine parvovirus-hepatitis infection is most frequently detected in Austrian horses of advanced age.Equine veterinary journal · 2022Article
- Human Pegivirus Type 1: A Common Human Virus That Is Beneficial in Immune-Mediated Disease?Frontiers in immunology · 2022Review
- Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea.Veterinary sciences · 2021Article
- First Detection and Genetic Characterization of New Equine Parvovirus Species Circulating among Horses in Korea.Veterinary sciences · 2021Article
- Small but mighty: old and new parvoviruses of veterinary significance.Virology journal · 2021Review
- Investigation of Three Newly Identified Equine Parvoviruses in Blood and Nasal Fluid Samples of Clinically Healthy Horses and Horses with Acute Onset of Respiratory Disease.Animals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
24 authors at 14 institutions in 2 countries.
Funding
Abstract
backgroundThree flaviviruses (equine pegivirus [EPgV]; Theiler's disease-associated virus [TDAV]; non-primate hepacivirus [NPHV]) and equine parvovirus (EqPV-H) are present in equine blood products; the TDAV, NPHV, and EqPV-H have been suggested as potential causes of serum hepatitis.
objectiveTo determine the prevalence of these viruses in horses with equine serum hepatitis. ANIMALS: Eighteen horses diagnosed with serum hepatitis, enrolled from US referral hospitals.
methodsIn the prospective case study, liver, serum, or both samples were tested for EPgV, TDAV, NPHV, and EqPV-H by PCR.
resultsBoth liver tissue and serum were tested for 6 cases, serum only for 8 cases, and liver only for 4 cases. Twelve horses received tetanus antitoxin (TAT) 4-12.7 weeks (median = 8 weeks), 3 horses received commercial equine plasma 6-8.6 weeks, and 3 horses received allogenic stem cells 6.4-7.6 weeks before the onset of hepatic failure. All samples were TDAV negative. Two of 14 serum samples were NPHV-positive. Six of 14 serum samples were EPgV-positive. All liver samples were NPHV-negative and EPgV-negative. EqPV-H was detected in the serum (N = 8), liver (N = 4), or both samples (N = 6) of all 18 cases. The TAT of the same lot number was available for virologic testing in 10 of 12 TAT-associated cases, and all 10 samples were EqPV-H positive. CONCLUSIONS AND CLINICAL IMPORTANCE: We demonstrated EqPV-H in 18 consecutive cases of serum hepatitis. EPgV, TDAV, and NPHV were not consistently present. This information should encourage blood product manufacturers to test for EqPV-H and eliminate EqPV-H-infected horses from their donor herds.
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Registered trials
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