ArticleBrain imaging and behavior2020
White matter microstructure varies with post-traumatic stress severity following medical trauma.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- A Diagnosis Model of Typhoon-Related Post-Traumatic Stress Disorder Based on Fixel-Based Analysis in Machine Learning.Brain and behavior · 2026Article
- Neurobiological and psychological indicators of post-traumatic stress symptoms in children and adolescents treated for a posterior fossa brain tumour.Neuroimage. Reports · 2026Article
- Stress-related white matter microstructure alterations and chronic pain.Brain imaging and behavior · 2026Article
- Use of Single Prolonged Stress to Model Post-traumatic Stress Disorder in Rodents: What We Found and Where to Next?Current neuropharmacology · 2026Review
- Childhood Adversity Is Associated With Longitudinal White Matter Changes After Adulthood Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.medRxiv : the preprint server for health sciences · 2025Article
- Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Probing the neurocardiac circuit in trauma and posttraumatic stress.Journal of psychiatric research · 2024Article
- Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure.Molecular psychiatry · 2023Article
- Initial assessment of medical post-traumatic stress among patients with chronic esophageal diseases.Neurogastroenterology and motility · 2023Article
- Increased fiber density of the fornix in patients with chronic tinnitus revealed by diffusion-weighted MRI.Frontiers in neuroscience · 2023Article
- Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.Translational psychiatry · 2022Article
- Acute Posttraumatic Symptoms Are Associated With Multimodal Neuroimaging Structural Covariance Patterns: A Possible Role for the Neural Substrates of Visual Processing in Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Psychoradiological abnormalities in treatment-naive noncomorbid patients with posttraumatic stress disorder.Depression and anxiety · 2022Article
- White Matter Microstructure in the Young Adult Brain Varies with Neighborhood Disadvantage in Adolescence.Neuroscience · 2021Article
- Opposing relationships of childhood threat and deprivation with stria terminalis white matter.Human brain mapping · 2021Article
- Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors.Diagnostics (Basel, Switzerland) · 2021Article
- Multimodal structural neuroimaging markers of risk and recovery from posttrauma anhedonia: A prospective investigation.Depression and anxiety · 2021Article
- Acute White Matter Integrity Post-trauma and Prospective Posttraumatic Stress Disorder Symptoms.Frontiers in human neuroscience · 2021Article
- Nervous and Endocrine System Dysfunction in Posttraumatic Stress Disorder: An Overview and Consideration of Sex as a Biological Variable.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The prefrontal cortex, amygdala, hippocampus, and hypothalamus are important components of the neural network that mediates the healthy learning, expression, and regulation of emotion. These brain regions are connected by white matter pathways that include the cingulum bundle, uncinate fasciculus, and fornix/stria terminalis. Individuals with trauma and stress-related disorders show dysfunction of the cognitive-affective processes supported by the brain regions these white matter tracts connect. Therefore, variability in the microstructure of these white matter pathways may play an important role in the cognitive-affective dysfunction related to post-traumatic stress disorder. Thus, the current study used diffusion weighted imaging to assess the white matter microstructure of the cingulum bundle, uncinate fasciculus, and fornix/stria terminalis acutely (< 1 month) following trauma. Further, we assessed both acute (i.e., < 1 month) and subacute (i.e., 3 months post-trauma) post-traumatic stress symptom severity. White matter microstructure (assessed < 1 month post-trauma) of the uncinate fasciculus and fornix/stria terminalis varied with acute post-traumatic stress severity (assessed < 1 month post-trauma). Further, white matter microstructure (assessed < 1 month post-trauma) of the cingulum bundle and fornix/stria terminalis varied with subacute post-traumatic stress severity (assessed 3 months post-trauma). The current results suggest white matter architecture of the prefrontal cortex - amygdala network plays an important role in the development of trauma and stress-related disorders.
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Registered trials
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