Evidence map›Paper›PMID 30519933›Full record

ArticleEuropean radiology2019

Multiparametric whole-body 3.0-T MRI in newly diagnosed intermediate- and high-risk prostate cancer: diagnostic accuracy and interobserver agreement for nodal and metastatic staging.

Edward William Johnston, Arash Latifoltojar, Harbir Singh Sidhu, Navin Ramachandran, Magdalena Sokolska, Alan Bainbridge, Caroline Moore, Hashim Uddin Ahmed, Shonit Punwani

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06071195 (All-in-One Prostate Cancer Staging with MRI), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06071195 recruitingnot on this mapstarted 2021, after this paper: background citation

All-in-One Prostate Cancer Staging with MRI

TypeobservationalSponsorEuropean Institute of OncologyRan2021 to 2026Enrolled400ConditionsProstate CancerArmsProstate Cancer Patients
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  12. Prospective comparison ofEuropean journal of nuclear medicine and molecular imaging · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Edward William JohnstonUCL Centre for Medical Imaging, 2nd Floor Charles Bell House, 43 - 45 Foley Street, London, W1W 7TS, UK.
Arash LatifoltojarUCL Centre for Medical Imaging, 2nd Floor Charles Bell House, 43 - 45 Foley Street, London, W1W 7TS, UK.
Harbir Singh SidhuUCL Centre for Medical Imaging, 2nd Floor Charles Bell House, 43 - 45 Foley Street, London, W1W 7TS, UK.
Navin RamachandranUCL Centre for Medical Imaging, 2nd Floor Charles Bell House, 43 - 45 Foley Street, London, W1W 7TS, UK.
Magdalena SokolskaMedical Physics, University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.
Alan BainbridgeMedical Physics, University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.
Caroline MooreDepartment of Urology, University College Hospital, 235 Euston Road, London, NW1 2BU, UK.
Hashim Uddin AhmedDepartment of Urology, Imperial College London, Fulham Palace Road, Hammersmith, London, W6 8RF, UK.
Shonit PunwaniUCL Centre for Medical Imaging, 2nd Floor Charles Bell House, 43 - 45 Foley Street, London, W1W 7TS, UK. shonit.punwani@gmail.com.ORCID http://orcid.org/0000-0001-9865-0260
The Folklore Society · GBUniversity College Hospital · GBHammersmith Hospital · GBTrinity House · GB

Funding

Cancer Research UK 16463
6 · The paper itself

Abstract

objectivesTo determine the diagnostic accuracy and interobserver concordance of whole-body (WB)-MRI, vs.

methodsAn institutional review board approved prospective cohort study carried out between July 2012 and November 2015, whereby 56 men prospectively underwent 3.0-T multiparametric (mp)-WB-MRI in addition to BS (all patients) ±

resultsThe mean sensitivity/specificity of WB-MRI for N1 disease was 1.00/0.96 respectively, compared with 1.00/0.82 for

conclusionsWB-MRI provides high levels of diagnostic accuracy for both nodal and metastatic bone disease, with higher levels of sensitivity than BS for metastatic disease, and similar performance to KEY POINTS: • A whole-body MRI protocol comprising unenhanced mDixon and diffusion-weighted imaging provides high levels of diagnostic accuracy for the primary staging of intermediate- and high-risk prostate cancer. • The diagnostic accuracy of whole-body MRI is much higher than that of bone scintigraphy, as currently recommended for clinical use. • Staging using WB-MRI, rather than bone scintigraphy, could result in better patient stratification and treatment delivery than is currently provided to patients worldwide.

Indexed as

AgedAged, 80 and overBone NeoplasmsDiffusion Magnetic Resonance ImagingHumansLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm StagingPositron Emission Tomography Computed TomographyProspective StudiesProstatic NeoplasmsReproducibility of ResultsROC CurveWhole Body ImagingCholineMagnetic resonance imagingPositron emission tomographyProstate

Identifiers

PMID30519933
PMCPMC6510859
OpenAlexW2902846261

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.