Evidence map›Paper›PMID 30519912›Full record

ArticleEnvironmental science and pollution research international2019

Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes.

Fatemeh Kargar Shouroki, Masoud Neghab, Hossein Mozdarani, Hamzeh Alipour, Saeed Yousefinejad, Reza Fardid

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Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Article
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  6. Molecular-based detection ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fatemeh Kargar ShourokiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Masoud NeghabDepartment of Occupational Health Engineering, Research Center for Health Sciences, Institute of Health, School of Health, Shiraz University of Medical Sciences, P.O. Box: 71645-111, Shiraz, Iran. neghabm@sums.ac.ir.
Hossein MozdaraniDepartment of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Hamzeh AlipourResearch Center for Health Sciences, Institute of health, Shiraz University of Medical Sciences, Shiraz, Iran.
Saeed YousefinejadDepartment of Occupational Health Engineering, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Reza FardidDepartment of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IRTarbiat Modares University · IR

Funding

Shiraz University of Medical Sciences 95-01-04-12366
6 · The paper itself

Abstract

Due to their wide applications, concern exists regarding possible genotoxic effects of inhalational anesthetics (IAs) among operating room personnel. This study was undertaken to examine genotoxic properties of co-exposure to nitrous oxide, sevoflurane, and isoflurane on induction of micronucleus (MN) and chromosomal aberrations (CAs) and to determine whether any associations exist between polymorphisms of GST genes and the level of genomic damage measured by MN and CAs assays. Sixty operating room personnel and 60 unexposed referent nurses were studied. The workers' exposure to the IAs was determined. DNA damage was evaluated by MN and CAs assays. Additionally, the GSTM1, GSTT1, and GSTP1 polymorphisms were detected. The mean concentrations of nitrous oxide, isoflurane, and sevoflurane were found to be 850.92 ± 919.78, 2.40 ± 0.86, and 0.18 ± 0.14 ppm, respectively. The frequency of MN and CAs in the exposed group was significantly higher than that of the non-exposed group. The frequency of MN was significantly higher in referent nurses with null GSTT1, compared to referent nurses with positive GSTT1. The frequency of MN was significantly higher in exposed individuals carrying the combined genotype of GSTT1 (-), GSTM1 (-), and GSTP1 AG as compared with subjects carrying a combination of GSTT1 (+), GSTM1 (+), and GSTP1 AA. Statistically significant associations were noted between exposure to the IAs, gender, and the combination of the three GSTs genotypes with MN frequency. These findings indicate that inhalation exposure to IAs induces genotoxic response and the polymorphisms of GSTs genes might modulate the effect of exposure to IAs on MN.

Indexed as

Operating Room NursingPolymorphism, GeneticAdultAnesthetics, InhalationChromosome AberrationsCross-Sectional StudiesDNA DamageFemaleGenotypeGlutathione S-Transferase piGlutathione TransferaseHumansMaleMicronucleus TestsMutagensNursesAnesthetics, InhalationGlutathione S-Transferase piglutathione S-transferase T1Glutathione TransferaseGSTP1 protein, humanMutagensChromosomal aberrationsGST genes polymorphismsMicronucleusOperating room

Identifiers

PMID30519912
OpenAlexW2903272094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.