Evidence map›Paper›PMID 30519873›Full record

ArticleChinese journal of integrative medicine2019

Acupuncture Regulates the Balance of CD4

Ming Dong, Wen-Qian Wang, Juan Chen, Mi-Hui Li, Fei Xu, Jie Cui, Jing-Cheng Dong, Ying Wei

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In one paragraph

Article in Chinese journal of integrative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Modulation of lung CD11bChinese medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ming DongGumei Community Health Center of Minhang District, Shanghai, 201102, China.
Wen-Qian WangDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Juan ChenDepartment of Pediatric Neurological Rehabilitation, Maternal and Child Health Hospital of Dengfeng, Dengfeng, 452470, Henan Province, China.
Mi-Hui LiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Fei XuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jie CuiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jing-Cheng DongDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ying WeiDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. weiying_acup@126.com.
Fudan University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the involvement of different CD4

methodsBALB/c mice were challenged by ovalbumin (OVA) for the establishment of experimental asthma model. Mice were divided into 4 groups by a random number table including the normal control, asthma model, acupuncture and sham acupuncture groups (14 per group). Acupoints Dazhui (GV 14), bilateral Fengmen (BL 12) and Feishu (BL 13) were selected for manual acupuncture treatment every other day for 4 weeks and Huantiao (GB 30) was selected for sham acupuncture. Airway hyperresponsiveness was examined by Buxco Pulmonary System. Pulmonary histopathology analysis was performed for inflammatory cell infiltration and mucus hypersecretion by haematoxylin eosin staining and periodic acid-Schiffstaining. Inflammatory mediators assays of serum were investigated by enzyme-linked immunosorbent assay and Bio-Plex. CD4

resultsCompared with the OVA-induced asthma model group, acupuncture could attenuate airway hyperresponsiveness, inhibit inflammatory cell infiltration and mucus hypersecretion (P<0.05 or P<0.01). Furthermore, acupuncture increased the expressions of T-bet and Foxp3

conclusionAcupuncture could alleviate allergic airway inflammation by strengthening the activities of Th1 and Treg, thus regulating the balance of CD4

Indexed as

Acupuncture TherapyAnimalsAsthmaCD4-Positive T-LymphocytesCytokinesFemaleInflammationLungMice, Inbred BALB CMitogen-Activated Protein Kinase 3p38 Mitogen-Activated Protein KinasesPhosphorylationRespiratory HypersensitivityCytokinesMitogen-Activated Protein Kinase 3p38 Mitogen-Activated Protein KinasesacupunctureasthmaTh17Th2Treg

Identifiers

PMID30519873
OpenAlexW2903534096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.