Observational studyOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019
Vertebral fractures cascade: potential causes and risk factors.
Observational study in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Machine learning-based risk predictive model for postoperative refractures in patients with osteoporotic vertebral compression fractures: a systematic review and critical appraisal.BMC musculoskeletal disorders · 2026Pooled it
- Lumbar localized fat distribution parameters are independent predictors of osteoporotic vertebral compression re-fractures (OVCRFs) following Percutaneous Kyphoplasty (PKP): a retrospective matched case-control study.Skeletal radiology · 2025Article
- Similarities in distribution pattern between acute multiple osteoporotic vertebral compression fractures and vertebral fractures cascades.Journal of orthopaedic surgery and research · 2024Article
- Towards the diagnosis of osteoporosis - contributions from coincidental diagnostic imaging findings in chiropractors' practice.Chiropractic & manual therapies · 2024Review
- Moving Beyond the 2018 Minimum International Care Considerations for Osteoporosis Management in Duchenne Muscular Dystrophy (DMD): Meeting Report from the 3rd International Muscle-Bone Interactions Meeting 7th and 14th November 2022.Journal of neuromuscular diseases · 2024Article
- Similarities and Differences in the Management of Patients with Osteoporotic Vertebral Fractures and Those with Rebound-Associated Vertebral Fractures Following Discontinuation of Denosumab.Journal of clinical medicine · 2023Review
- Comparison of thoracolumbar versus non-thoracolumbar osteoporotic vertebral compression fractures in risk factors, vertebral compression degree and pre-hospital back pain.Journal of orthopaedic surgery and research · 2023Article
- Observational
- Comparison of acute single versus multiple osteoporotic vertebral compression fractures in radiographic characteristic and bone fragility.Journal of orthopaedic surgery and research · 2023Article
- Study on the Optimal Surgical Scheme for Very Severe Osteoporotic Vertebral Compression Fractures.Orthopaedic surgery · 2023Article
- Computed tomography-based paravertebral muscle density predicts subsequent vertebral fracture risks independently of bone mineral density in postmenopausal women following percutaneous vertebral augmentation.Aging clinical and experimental research · 2022Article
- A bibliometric and visualization analysis of glucocorticoid-induced osteoporosis research from 2012 to 2021.Frontiers in endocrinology · 2022Article
- Vertebral fracture: epidemiology, impact and use of DXA vertebral fracture assessment in fracture liaison services.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Risk factors for subsequent vertebral fractures following a previous hip fracture.Journal of bone and mineral metabolism · 2021Article
- Denosumab Discontinuation and the Rebound Phenomenon: A Narrative Review.Journal of clinical medicine · 2021Review
- Consequence of vertebral fracture cascades: about a cohort of 79 patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Hybrid stabilization of unstable osteoporotic thoracolumbar vertebral body fractures: clinical and radiological outcome after a mean of 4 years.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
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12 authors at 9 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We performed a study to identify potential causes and risk factors of vertebral fracture cascade. Vertebral fracture cascade is a severe clinical event in patients with bone fragility. Only half of patients have an identified cause of secondary osteoporosis.
introductionVertebral fracture (VF) is the most common osteoporotic fracture, and a strong risk factor of subsequent VFs leading to VF cascade (VFC). We prompted a study to identify potential causes and risk factors of VFC.
methodsVFC observations were collected retrospectively between January 2016 and April 2017. VFC was defined as an occurrence of at least three VFs within 1 year.
resultsWe included in 10 centers a total of 113 patients with VFC (79.6% of women, median age 73, median number of VFs in the cascade, 5). We observed 40.5% and 30.9% of patients with previous major fractures and a previous VF, respectively, and 68.6% with densitometric osteoporosis; 18.9% of patients were currently receiving oral glucocorticoids and 37.1% in the past. VFC was attributed by the physician to postmenopausal osteoporosis in 54% of patients. A secondary osteoporosis associated with the VFC was diagnosed in 52 patients: glucocorticoid-induced osteoporosis (25.7%), non-malignant hemopathies (6.2%), alcoholism (4.4%), use of aromatase inhibitors (3.6%), primary hyperparathyroidism (2.7%), hypercorticism (2.7%), anorexia nervosa (2.7%), and pregnancy and lactation-associated osteoporosis (1.8%). A total of 11.8% of cases were reported following a vertebroplasty procedure. A total of 31.5% patients previously received an anti-osteoporotic treatment. In six patients, VFC occurred early after discontinuation of an anti-osteoporotic treatment, in the year after the last dose effect was depleted: five after denosumab and one after odanacatib.
conclusionThe results of this retrospective study showed that only half of VFC occurred in patients with a secondary cause of osteoporosis. Prospective studies are needed to further explore the determinants of this severe complication of osteoporosis.
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