Evidence map›Paper›PMID 30519707›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2019

Inhibition by general anesthetic propofol of compound action potentials in the frog sciatic nerve and its chemical structure.

Nobuya Magori, Tsugumi Fujita, Kotaro Mizuta, Eiichi Kumamoto

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nobuya MagoriDepartment of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
Tsugumi FujitaDepartment of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
Kotaro MizutaDepartment of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
Eiichi KumamotoDepartment of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan. kumamote@cc.saga-u.ac.jp.
Saga Medical School Hospital · JP

Funding

JSPS KAKENHI 15K08673
6 · The paper itself

Abstract

Although the intravenous general anesthetic propofol (2,6-diisopropylphenol) has an ability to inhibit nerve conduction, this has not been fully examined. Various agents inhibit compound action potentials (CAPs) in a manner dependent on their chemical structures. To determine propofol's chemical structure that is important in nerve conduction inhibition, we examined the effects of propofol and its related compounds on fast-conducting CAPs recorded from the frog sciatic nerve by using the air-gap method. Propofol concentration-dependently reduced the peak amplitude of the CAP with a half-maximal inhibitory concentration (IC

Indexed as

Action PotentialsAlcoholsAnesthetics, GeneralAnesthetics, LocalAnimalsBenzocaineFemaleKetonesMalePhenolsRanidaeSciatic NerveAlcoholsAnesthetics, GeneralAnesthetics, LocalBenzocaineKetonesPhenolsAnalgesiaBenzocaineCompound action potentialFrog sciatic nerveNerve conductionPropofol

Identifiers

PMID30519707
OpenAlexW2902019118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.