ArticleBioMed research international2018
Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Platelets in preeclampsia: an observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape.BMC medicine · 2025Observational
- Expression and clinical significance of platelet-derived miR-145-5p and miR-6805-3p in diabetic kidney disease patients.Frontiers in medicine · 2025Article
- Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches.International journal of oral science · 2024Review
- Platelet Rich Plasma Therapy in Achilles and Patellar Tendinopathies: Outcomes in Subjects with Diabetes (A Retrospective Case-Control Study).Journal of clinical medicine · 2024Article
- Single-cell analysis of platelets from patients with periodontitis and diabetes.Research and practice in thrombosis and haemostasis · 2023Article
- Article
- Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis.PloS one · 2022Article
- Platelet microRNAs and vascular injury.The Journal of clinical investigation · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus (DM) has been associated with increased platelet reactivity as well as increased levels of platelet RNAs in plasma. Here, we sought to evaluate whether the platelet transcriptome is altered in the presence of uncontrolled DM.
methodsNext-generation sequencing (NGS) was performed on platelet RNA for 5 patients with uncontrolled DM (HbA1c 9.0%) and 5 control patients (HbA1c 5.5%) with otherwise similar clinical characteristics. RNA was isolated from leucocyte-depleted platelet-rich plasma. Libraries of platelet RNAs were created separately for long RNAs after ribosomal depletion and for small RNAs from total RNA, followed by next-generation sequencing.
resultsPlatelets in both groups demonstrated RNA expression profiles characterized by absence of leukocyte-specific transcripts, high expression of well-known platelet transcripts, and in total 6,343 consistently detectable transcripts. Extensive statistical bioinformatic analysis yielded 12 genes with consistently differential expression at a lenient FDR < 0.1, thereof 8 protein-coding genes and 2 genes with known expression in platelets (
conclusionsIn this study, uncontrolled DM had a remote impact on different components of the platelet transcriptome. Increased expression of
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Registered trials
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