ArticlePeerJ2018
Taxonomic patterns in the zoonotic potential of mammalian viruses.
Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Temporal and spatial limitations in global surveillance for bat filoviruses and henipaviruses.Biology letters · 2019Pooled it
- Viral epidemic potential is not uniformly distributed across the bat phylogeny.Communications biology · 2025Article
- Making sense of the virome in light of evolution and ecology.Proceedings. Biological sciences · 2025Review
- Optimising predictive models to prioritise viral discovery in zoonotic reservoirs.The Lancet. Microbe · 2022Review
- Bats host the most virulent-but not the most dangerous-zoonotic viruses.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The science of the host-virus network.Nature microbiology · 2021Review
- The future of zoonotic risk prediction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Identifying and prioritizing potential human-infecting viruses from their genome sequences.PLoS biology · 2021Article
- Impacts of biodiversity and biodiversity loss on zoonotic diseases.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Taxonomic resolution affects host-parasite association model performance.Parasitology · 2021Article
- Zoonotic spillover: Understanding basic aspects for better prevention.Genetics and molecular biology · 2021Article
- Implications of Zoonoses From Hunting and Use of Wildlife in North American Arctic and Boreal Biomes: Pandemic Potential, Monitoring, and Mitigation.Frontiers in public health · 2021Review
- Identifying Suspect Bat Reservoirs of Emerging Infections.Vaccines · 2020Article
- Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The problem of scale in the prediction and management of pathogen spillover.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Predicting and simplifying which pathogens may spill over from animals to humans is a major priority in infectious disease biology. Many efforts to determine which viruses are at risk of spillover use a subset of viral traits to find trait-based associations with spillover. We adapt a new method-phylofactorization-to identify not traits but lineages of viruses at risk of spilling over. Phylofactorization is used to partition the International Committee on Taxonomy of Viruses viral taxonomy based on non-human host range of viruses and whether there exists evidence the viruses have infected humans. We identify clades on a range of taxonomic levels with high or low propensities to spillover, thereby simplifying the classification of zoonotic potential of mammalian viruses. Phylofactorization by whether a virus is zoonotic yields many disjoint clades of viruses containing few to no representatives that have spilled over to humans. Phylofactorization by non-human host breadth yields several clades with significantly higher host breadth. We connect the phylogenetic factors above with life-histories of clades, revisit trait-based analyses, and illustrate how cladistic coarse-graining of zoonotic potential can refine trait-based analyses by illuminating clade-specific determinants of spillover risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.