ArticleTranslational vision science & technology2018
Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.
Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
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- RHO1-2 meganuclease gene editing targets human P23H rhodopsin-induced retinitis pigmentosa to rejuvenate rods and maintain cones.bioRxiv : the preprint server for biology · 2025Article
- Correlation of retinal fluid and photoreceptor and RPE loss in neovascular AMD by automated quantification, a real-world FRB! analysis.Acta ophthalmologica · 2025Article
- A mobile system for whole eye perfusion supporting retinal function and surgery.Frontiers in bioengineering and biotechnology · 2025Article
- A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes.Disease models & mechanisms · 2023Article
- Mapping Retinal Abnormalities in Psychosis: Meta-analytical Evidence for Focal Peripapillary and Macular Reductions.Schizophrenia bulletin · 2022Article
- In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography.Translational vision science & technology · 2022Article
- OCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health.Scientific reports · 2022Article
- Normative Data of Axial Length, Retinal Thickness Measurements, Visual Evoked Potentials, and Full-Field Electroretinography in Female, Wild-Type Minipigs.Translational vision science & technology · 2021Article
- In vivo imaging of the inner retinal layer structure in mice after eye-opening using visible-light optical coherence tomography.Experimental eye research · 2021Article
- A Common Outer Retinal Change in Retinal Degeneration by Optical Coherence Tomography Can Be Used to Assess Outcomes of Gene Therapy.Human gene therapy · 2019Article
- Noninvasive Imaging and Correlative Histology of Cone Photoreceptor Structure in the Pig Retina.Translational vision science & technology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe correlate optical coherence tomography (OCT) retinal layer thickness measurements with histology in wild-type and retinal degenerative pigs.
methodsOCT scans were obtained using the Bioptigen Envisu R2200. In normal pigs, three eyes were imaged in vivo, and three eyes were imaged after enucleation. In the Pro23His retinal degeneration pigs (P23H), one eye was imaged in vivo and four eyes were imaged after enucleation. All eyes were fixed in 4% paraformaldehyde and processed for histology. Corresponding retinal locations on OCT and histology were identified using anatomic landmarks (optic nerve, retinal vessels, visual streak). Individual retinal layer thicknesses were measured by two independent, masked graders, and intraclass correlation coefficients were used to determine agreement. OCT and histologic retinal thickness measurements were averaged and compared.
resultsOCT and histologic measurements correlated highly in normal and diseased eyes (
conclusionsRetinal layer thickness measurements correlate well with histology in pig eyes, but differences in individual retinal layers may be seen. TRANSLATIONAL RELEVANCE: OCT may be used in pigs to measure retinal thicknesses with good overall correlation to histologic measurements.
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Registered trials
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