ArticleJournal of therapeutic ultrasound2018
Focused ultrasound for the treatment of bone metastases: effectiveness and feasibility.
Article in Journal of therapeutic ultrasound, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01091883 (Phase IIIA Study Comparing the Safety and Effectiveness of MR Guided Focused Ultrasound and External Beam Radiation for Treatment of Metastatic Bone Tumors and Multiple Myeloma), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase IIIA Study Comparing the Safety and Effectiveness of MR Guided Focused Ultrasound and External Beam Radiation for Treatment of Metastatic Bone Tumors and Multiple Myeloma
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Efficacy and safety of magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: a systematic review and meta-analysis.Skeletal radiology · 2021Pooled it
- The Roles of Magnetic Resonance-Guided Focused Ultrasound in Pain Relief in Patients With Bone Metastases: A Systemic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Interventional Radiology in the Treatment of Musculoskeletal Tumours.Current oncology (Toronto, Ont.) · 2026Review
- Therapeutic Ultrasound for Multimodal Cancer Treatment: A Spotlight on Breast Cancer.Annual review of biomedical engineering · 2025Review
- Modern Treatment of Skeletal Metastases: Multidisciplinarity and the Concept of Oligometastasis in the Recent Literature.Current oncology (Toronto, Ont.) · 2025Review
- Update on musculoskeletal applications of magnetic resonance-guided focused ultrasound.Skeletal radiology · 2024Review
- US-Guided Interventional Procedures for Total Hip Arthroplasty.Journal of clinical medicine · 2024Review
- Review of Robot-Assisted HIFU Therapy.Sensors (Basel, Switzerland) · 2023Review
- Article
- High Intensity Focused Ultrasound for Treatment of Bone Malignancies-20 Years of History.Cancers · 2022Review
- Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials.Discover oncology · 2022Review
- Review
- Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions.Journal of clinical medicine · 2022Review
- Interventional Radiology in the Management of Metastases and Bone Tumors.Journal of clinical medicine · 2022Review
- Review
- Electrochemotherapy Is Effective in the Treatment of Bone Metastases.Current oncology (Toronto, Ont.) · 2022Article
- Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment.International journal of radiation oncology, biology, physics · 2021Article
- Combining radiotherapy and focused ultrasound for pain palliation of cancer induced bone pain; a stage I/IIa study according to the IDEAL framework.Clinical and translational radiation oncology · 2021Article
- Focused Ultrasound for Immunomodulation of the Tumor Microenvironment.Journal of immunology (Baltimore, Md. : 1950) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the effectiveness and feasibility of high-intensity focused ultrasound (HIFU) for the treatment of bone metastases.
methodsA single-center prospective study was made involving 17 consecutive patients with symptomatic bone metastases. Patients were treated by Focused Ultrasound (FUs) performed with magnetic resonance (MR) guidance. Surgical treatment or radiotherapy treatment was not indicated for patients who underwent FUs. Lesions were located in the appendicular and axial skeleton and consisted of secondary symptomatic lesions. The clinical course of pain was evaluated using the Visual Analog Scale (VAS) before treatment, at 1 week, and at 1 month after treatment and the Oral Morphine Equivalent Daily Dose (OMEDD) was also recorded. We used Wilcoxon signed rank test to assess change in patient pain (R CRAN software V 3.1.1).
resultsWe observed a significant decrease in the pain felt by patients between pre- procedure and 1 week post-procedure (
conclusionsHIFU under MR-guidance seems to be an effective and safe procedure in the treatment of symptomatic bone lesions for patients suffering from metastatic disease. A significant decrease of patient pain was observed.
trial registrationNCT01091883. Registered 24 March 2010. Level of evidence: Level 3.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.