Evidence map›Paper›PMID 30519453›Full record

ReviewF1000Research2018

RNA interactomics: recent advances and remaining challenges.

Brigitte Schönberger, Christoph Schaal, Richard Schäfer, Björn Voß

Abstract readReview
In one paragraph

Review in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Bioinformatic Tools for the Analysis and Prediction of ncRNA Interactions.International journal of molecular sciences · 2021
    Review
  10. Article
  11. RNA sequencing: the teenage years.Nature reviews. Genetics · 2019
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brigitte SchönbergerInstitute of Biochemical Engineering, Computational Biology Group, University of Stuttgart, Stuttgart, 70569, Germany.
Christoph SchaalInstitute of Biochemical Engineering, Computational Biology Group, University of Stuttgart, Stuttgart, 70569, Germany.
Richard SchäferInstitute of Biochemical Engineering, Computational Biology Group, University of Stuttgart, Stuttgart, 70569, Germany.
Björn VoßInstitute of Biochemical Engineering, Computational Biology Group, University of Stuttgart, Stuttgart, 70569, Germany.ORCID 0000-0002-5377-2800

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tight regulation of cellular processes is key to the development of complex organisms but also vital for simpler ones. During evolution, different regulatory systems have emerged, among them RNA-based regulation that is carried out mainly by intramolecular and intermolecular RNA-RNA interactions. However, methods for the transcriptome-wide detection of these interactions were long unavailable. Recently, three publications described high-throughput methods to directly detect RNA duplexes in living cells. This promises to enable in-depth studies of RNA-based regulation and will narrow the gaps in our understanding of RNA structure and function. In this review, we highlight the benefits of these methods and their commonalities and differences and, in particular, point to methodological shortcomings that hamper their wider application. We conclude by presenting ideas for how to overcome these problems and commenting on the prospects we see in this area of research.

Indexed as

TranscriptomeAnimalsHigh-Throughput Nucleotide SequencingHumansRNARNARegulationRNARNA-RNA interactions

Identifiers

PMID30519453
PMCPMC6248267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.