Evidence map›Paper›PMID 30519240›Full record

ArticleFrontiers in immunology2018

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death.

Zhengzhao Liu, Hongming Li, Chungu Hong, Menglu Chen, Tao Yue, Chunyuan Chen, Zhenxing Wang, Qing You, Chuanyin Li, Qinjie Weng and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 67 citations in OpenAlex.

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  18. Modelling amyotrophic lateral sclerosis in rodents.Nature reviews. Neuroscience · 2022
    Review
  19. Article
  20. Altered Mitochondrial Protein Homeostasis and Proteinopathies.Frontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Zhengzhao LiuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Hongming LiMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Chungu HongMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Menglu ChenMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Tao YueMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Chunyuan ChenMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Zhenxing WangMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Qing YouState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Shanghai, China.
Chuanyin LiState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Shanghai, China.
Qinjie WengInstitute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Center for Drug Safety Evaluation and Research, Zhejiang University, Hangzhou, China.
Hui XieMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Ronggui HuState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Shanghai, China.
Xiangya Hospital Central South University · CNCentral South University · CNShanghaiTech University · CNNational Clinical Research Center for Digestive Diseases · CNShenzhen Second People's Hospital · CNUniversity of Chinese Academy of Sciences · CNZheJiang Institute For Food and Drug Control · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles. The etiologies vary among different subtypes of ALS, and no effective management or medication could be provided to the patients, with the underlying mechanisms incompletely understood yet. Mutations in human

Indexed as

Mutation, MissenseAmino Acid SubstitutionAmyotrophic Lateral SclerosisAnimalsCell Cycle ProteinsCell DeathEmbryo, MammalianEye ProteinsFibroblastsHumansMembrane Transport ProteinsMiceNeuronsTranscription Factor TFIIIACell Cycle ProteinsEye ProteinsMembrane Transport ProteinsOPTN protein, humanOptn protein, mouseTranscription Factor TFIIIAALScell deathcytokinesinflammationoptineurin

Identifiers

PMID30519240
PMCPMC6251386
OpenAlexW2901044417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.